2. Protein Tyrosine Kinase/RTK
  3. VEGFR PDGFR
  4. VEGFR-2-IN-44

VEGFR-2-IN-44 (compound 4b) is a selective VEGF-R2 (Flk-1) inhibitor with an IC50 value of 70 nM. VEGFR-2-IN-44 also inhibits PDGF-Rβ with an IC50 of 920 nM.

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VEGFR-2-IN-44 Chemical Structure

VEGFR-2-IN-44 Chemical Structure

CAS No. : 288144-20-7

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VEGFR-2-IN-44 Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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PDGFR PDGFRβ PDGFRα

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Description

VEGFR-2-IN-44 (compound 4b) is a selective VEGF-R2 (Flk-1) inhibitor with an IC50 value of 70 nM. VEGFR-2-IN-44 also inhibits PDGF-Rβ with an IC50 of 920 nM[1].

IC50 & Target[1]

Flk-1

70 nM (IC50)

PDGFR-β

920 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HUVEC IC50
> 50 μM
Compound: 4b
Evaluated for the inhibition of cell proliferation induced by EGF in HUVEC or NIH3T3 cells
Evaluated for the inhibition of cell proliferation induced by EGF in HUVEC or NIH3T3 cells
[PMID: 10893303]
HUVEC IC50
0.11 μM
Compound: 4b
Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or NIH3T3 cells
Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or NIH3T3 cells
[PMID: 10893303]
HUVEC IC50
2.01 μM
Compound: 4b
Evaluated for the inhibition of cell proliferation induced by PDGF in HUVEC or NIH3T3 cells
Evaluated for the inhibition of cell proliferation induced by PDGF in HUVEC or NIH3T3 cells
[PMID: 10893303]
HUVEC IC50
24.6 μM
Compound: 4b
Evaluated for the inhibition of cell proliferation induced by FGF in HUVEC or NIH3T3 cells
Evaluated for the inhibition of cell proliferation induced by FGF in HUVEC or NIH3T3 cells
[PMID: 10893303]
Molecular Weight

343.22

Formula

C17H15BrN2O
CAS No.
SMILES

O=C(/C(C1=C2)=C\C3=CC4=C(CCCC4)N3)NC1=CC=C2Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-2-IN-44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-44288144-20-7VEGFRPDGFRVascular endothelial growth factor receptorPlatelet-derived growth factor receptorVEGFR2 (Flk-1)PDGF-RβInhibitorinhibitorinhibit

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Cat. No.:
HY-112337
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