2. Apoptosis Autophagy
  3. Bcl-2 Family Autophagy
  4. Venetoclax-d8

Venetoclax-d8  (Synonyms: ABT-199-d8; GDC-0199-d8; RG7601-d8)

Cat. No.: HY-15531S Purity: 99.76%
SDS COA Handling Instructions

Molarity Calculator

Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

For research use only. We do not sell to patients.

Venetoclax-d<sub>8</sub> Chemical Structure

Venetoclax-d8 Chemical Structure

CAS No. : 1257051-06-1

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1 mg USD 390 In-stock
5 mg USD 980 In-stock
10 mg USD 1560 In-stock
25 mg USD 3120 In-stock
50 mg USD 4990 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Venetoclax-d8:

Venetoclax-d8 Related Antibodies

Top Publications Citing Use of Products

View All Bcl-2 Family Isoform Specific Products:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Venetoclax-d8 Related Antibodies
Molecular Weight

876.49

Formula

C45H42D8ClN7O7S
CAS No.
Unlabeled CAS

1257044-40-8
Appearance

Solid

Color

White to yellow

SMILES

O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4C([2H])([2H])C([2H])([2H])N(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)C([2H])([2H])C4([2H])[2H])C=C3OC7=CN=C(NC=C8)C8=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (114.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1409 mL 5.7046 mL 11.4091 mL
5 mM 0.2282 mL 1.1409 mL 2.2818 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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=
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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.76%

SDS (252 KB)

COA (252 KB) HNMR (136 KB) RP-HPLC (139 KB) LCMS (382 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1409 mL 5.7046 mL 11.4091 mL 28.5229 mL
5 mM 0.2282 mL 1.1409 mL 2.2818 mL 5.7046 mL
10 mM 0.1141 mL 0.5705 mL 1.1409 mL 2.8523 mL
15 mM 0.0761 mL 0.3803 mL 0.7606 mL 1.9015 mL
20 mM 0.0570 mL 0.2852 mL 0.5705 mL 1.4261 mL
25 mM 0.0456 mL 0.2282 mL 0.4564 mL 1.1409 mL
30 mM 0.0380 mL 0.1902 mL 0.3803 mL 0.9508 mL
40 mM 0.0285 mL 0.1426 mL 0.2852 mL 0.7131 mL
50 mM 0.0228 mL 0.1141 mL 0.2282 mL 0.5705 mL
60 mM 0.0190 mL 0.0951 mL 0.1902 mL 0.4754 mL
80 mM 0.0143 mL 0.0713 mL 0.1426 mL 0.3565 mL
100 mM 0.0114 mL 0.0570 mL 0.1141 mL 0.2852 mL
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Venetoclax-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Venetoclax-d81257051-06-1ABT-199-d8 GDC-0199-d8 RG7601-d8Bcl-2 FamilyAutophagyInhibitorinhibitorinhibit

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