2. Membrane Transporter/Ion Channel Anti-infection
  3. ATP Synthase Antibiotic
  4. Venturicidin A

Venturicidin A  (Synonyms: Aabomycin A1)

Cat. No.: HY-N125722 Purity: 95.0%
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Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

For research use only. We do not sell to patients.

Venturicidin A Chemical Structure

Venturicidin A Chemical Structure

CAS No. : 33538-71-5

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Based on 1 publication(s) in Google Scholar

Venturicidin A Related Antibodies

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Description

Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

IC50 & Target

Aminoglycoside

 

Cellular Effect
Cell Line Type Value Description References
B16 IC50
12 μM
Compound: 4
Cytotoxicity against mouse B16 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against mouse B16 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
[PMID: 33356258]
Hep 3B2 IC50
15 μM
Compound: 4
Cytotoxicity against human Hep3B cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against human Hep3B cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
[PMID: 33356258]
K562 IC50
5.8 μM
Compound: 4
Cytotoxicity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
[PMID: 33356258]
MDA-MB-468 IC50
8.3 μM
Compound: 4
Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
[PMID: 33356258]
MV4-11 IC50
0.09 μM
Compound: 4
Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
[PMID: 33356258]
Molecular Weight

749.97

Formula

C41H67NO11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC[C@](O)(C2)O[C@]1([H])/C(C)=C\CCC[C@](O[C@@]3([H])C[C@H]([C@H](O)[C@@H](C)O3)OC(N)=O)([H])/C=C/[C@H](C)C[C@@H](C)[C@]([C@H](C)C[C@@H](C)[C@H](O)[C@H](C)C(CC)=O)([H])OC2=O
Structure Classification
Initial Source

actinomycetes
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8 mg/mL (10.67 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3334 mL 6.6669 mL 13.3339 mL
5 mM 0.2667 mL 1.3334 mL 2.6668 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.0%

SDS (392 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3334 mL 6.6669 mL 13.3339 mL 33.3347 mL
5 mM 0.2667 mL 1.3334 mL 2.6668 mL 6.6669 mL
10 mM 0.1333 mL 0.6667 mL 1.3334 mL 3.3335 mL
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Venturicidin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Venturicidin A33538-71-5Aabomycin A1Aabomycin A 1Aabomycin A-1ATP SynthaseAntibioticATP synthaseaminoglycoside antibioticStaphylococcusEnterococcusPseudomonas aeruginosaembryonic-kidneyHEK cellsInhibitorinhibitorinhibit

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