2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. VER-00158411

VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively.

For research use only. We do not sell to patients.

VER-00158411 Chemical Structure

VER-00158411 Chemical Structure

CAS No. : 1174664-88-0

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VER-00158411 Related Antibodies

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Chk1 Chk2

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Description

VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively[1].

IC50 & Target[1]

Chk1

4.4 nM (IC50)

Chk2

4.5 nM (IC50)

In Vitro

Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (CHKs). There have been a number of clinical trial of checkpoint kinase inhibits alone or as a combination therapy for example, as a means to sensitize proliferating tumor cells to chemotherapies that damage DNA. The development of checkpoint kinase inhibitors the treatment of cancer was a major objective in drug discovery[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VER-00158411 Related Antibodies
Molecular Weight

538.64

Formula

C31H34N6O3
CAS No.
SMILES

O=C(C1=CN(CC2=CC=CC=C2)N=C1)NC(C=C3C(N4)=CC5=C4C=CC(OCC(C)(C)CN(C)C)=C5)=CNC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VER-00158411 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VER-001584111174664-88-0VER00158411VER 00158411Checkpoint Kinase (Chk)Inhibitorinhibitorinhibit

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HY-18942
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