2. Membrane Transporter/Ion Channel Anti-infection
  3. Potassium Channel Bacterial Antibiotic
  4. Verruculogen

Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca2+-activated K+ channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle.

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Verruculogen Chemical Structure

Verruculogen Chemical Structure

CAS No. : 12771-72-1

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Based on 1 publication(s) in Google Scholar

Verruculogen Related Antibodies

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Description

Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca2+-activated K+ channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle[1][2][3].

Molecular Weight

511.57

Formula

C27H33N3O7
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

C/C(C)=C\[C@@H]1N2C3=C([C@@H]([C@@]4(N(C([C@@]5([H])N(CCC5)C4=O)=O)[C@@]3([H])CC(C)(OO1)C)O)O)C6=CC=C(OC)C=C62
Structure Classification
Initial Source

Penicillium verruculosum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (97.74 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9548 mL 9.7738 mL 19.5477 mL
5 mM 0.3910 mL 1.9548 mL 3.9095 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9548 mL 9.7738 mL 19.5477 mL 48.8692 mL
5 mM 0.3910 mL 1.9548 mL 3.9095 mL 9.7738 mL
10 mM 0.1955 mL 0.9774 mL 1.9548 mL 4.8869 mL
15 mM 0.1303 mL 0.6516 mL 1.3032 mL 3.2579 mL
20 mM 0.0977 mL 0.4887 mL 0.9774 mL 2.4435 mL
25 mM 0.0782 mL 0.3910 mL 0.7819 mL 1.9548 mL
30 mM 0.0652 mL 0.3258 mL 0.6516 mL 1.6290 mL
40 mM 0.0489 mL 0.2443 mL 0.4887 mL 1.2217 mL
50 mM 0.0391 mL 0.1955 mL 0.3910 mL 0.9774 mL
60 mM 0.0326 mL 0.1629 mL 0.3258 mL 0.8145 mL
80 mM 0.0244 mL 0.1222 mL 0.2443 mL 0.6109 mL
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Verruculogen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Verruculogen12771-72-1Potassium ChannelBacterialAntibioticKcsAInhibitorinhibitorinhibit

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