VinclozolinM2-2204

Cat. No.: HY-161741 Purity: 98.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

VinclozolinM2-2204 is a androgen receptor (AR) AUTOTAC degrader, with an DC₅₀ of 200 nM in LNCaP prostate cancer cells. VinclozolinM2-2204 induces the formation of AR⁺LC3⁺ autophagic membranes. VinclozolinM2-2204 can be used for the research of cancer.(Pink: AR inhibitor (HY-168296); Black: linker (HY-128833); Blue: CRBN Ligand (HY-168293))

For research use only. We do not sell to patients.

VinclozolinM2-2204 Chemical Structure

Size		Stock
1 mg		Check price and availability
5 mg		Check price and availability
10 mg		Check price and availability

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
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Description

VinclozolinM2-2204 is a androgen receptor (AR) AUTOTAC degrader, with an DC₅₀ of 200 nM in LNCaP prostate cancer cells. VinclozolinM2-2204 induces the formation of AR⁺LC3⁺ autophagic membranes. VinclozolinM2-2204 can be used for the research of cancer^[1].(Pink: AR inhibitor (HY-168296); Black: linker (HY-128833); Blue: CRBN Ligand (HY-168293))

Molecular Weight

824.79

Formula

C₄₃H₅₁Cl₂N₃O₉

Appearance

Solid

Color

White to off-white

SMILES

O[C@H](CNCCOCCOCCNC(N(C1=CC(Cl)=CC(Cl)=C1)C(C(C)(O)C=C)=O)=O)COC2=CC(OCCC3=CC=CC=C3)=C(OCCC4=CC=CC=C4)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (121.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2124 mL	6.0621 mL	12.1243 mL
5 mM	0.2425 mL	1.2124 mL	2.4249 mL
10 mM	0.1212 mL	0.6062 mL	1.2124 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.00%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (245 KB) HNMR (235 KB) RP-HPLC (260 KB) LCMS (238 KB)

Handling Instructions (2659 KB)

References

[1]. Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13(1):904. doi: 10.1038/s41467-022-28520-4. Erratum in: Nat Commun. 2022 Apr 12;13(1):2108. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2124 mL	6.0621 mL	12.1243 mL	30.3107 mL
	5 mM	0.2425 mL	1.2124 mL	2.4249 mL	6.0621 mL
	10 mM	0.1212 mL	0.6062 mL	1.2124 mL	3.0311 mL
	15 mM	0.0808 mL	0.4041 mL	0.8083 mL	2.0207 mL
	20 mM	0.0606 mL	0.3031 mL	0.6062 mL	1.5155 mL
	25 mM	0.0485 mL	0.2425 mL	0.4850 mL	1.2124 mL
	30 mM	0.0404 mL	0.2021 mL	0.4041 mL	1.0104 mL
	40 mM	0.0303 mL	0.1516 mL	0.3031 mL	0.7578 mL
	50 mM	0.0242 mL	0.1212 mL	0.2425 mL	0.6062 mL
	60 mM	0.0202 mL	0.1010 mL	0.2021 mL	0.5052 mL
	80 mM	0.0152 mL	0.0758 mL	0.1516 mL	0.3789 mL
	100 mM	0.0121 mL	0.0606 mL	0.1212 mL	0.3031 mL