2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Vincristine-d3-ester sulfate

Vincristine-d3-ester sulfate  (Synonyms: Leurocristine-d3-ester sulfate; NSC-67574-d3-ester sulfate; 22-Oxovincaleukoblastine-d3-ester sulfate)

Cat. No.: HY-N0488S1 Purity: ≥99.0%
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Vincristine-d3-ester (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1].

For research use only. We do not sell to patients.

Vincristine-d<sub>3</sub>-ester sulfate Chemical Structure

Vincristine-d3-ester sulfate Chemical Structure

CAS No. : 1217854-24-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Vincristine-d3-ester sulfate:

Vincristine-d3-ester sulfate Related Antibodies

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Description

Vincristine-d3-ester (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vincristine-d3-ester sulfate Related Antibodies
Molecular Weight

926.05

Formula

C46H55D3N4O14S
CAS No.
Unlabeled CAS

2068-78-2
Appearance

Solid

Color

White to off-white

SMILES

S(=O)(=O)(O)O.C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C=O)C=5C4=CC(=C(OC)C5)[C@]6(C(OC([2H])([2H])[2H])=O)C7=C(C=8C(N7)=CC=CC8)CC[N@]9C[C@@](C6)(C[C@](CC)(O)C9)[H])[H])CCN3CC=C2)[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (89.98 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 83.33 mg/mL (89.98 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (53.99 mM; Need ultrasonic)

H2O : 50 mg/mL (53.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0799 mL 5.3993 mL 10.7986 mL
5 mM 0.2160 mL 1.0799 mL 2.1597 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 1.0799 mL 5.3993 mL 10.7986 mL 26.9964 mL
5 mM 0.2160 mL 1.0799 mL 2.1597 mL 5.3993 mL
10 mM 0.1080 mL 0.5399 mL 1.0799 mL 2.6996 mL
15 mM 0.0720 mL 0.3600 mL 0.7199 mL 1.7998 mL
20 mM 0.0540 mL 0.2700 mL 0.5399 mL 1.3498 mL
25 mM 0.0432 mL 0.2160 mL 0.4319 mL 1.0799 mL
30 mM 0.0360 mL 0.1800 mL 0.3600 mL 0.8999 mL
40 mM 0.0270 mL 0.1350 mL 0.2700 mL 0.6749 mL
50 mM 0.0216 mL 0.1080 mL 0.2160 mL 0.5399 mL
DMSO / DMSO 60 mM 0.0180 mL 0.0900 mL 0.1800 mL 0.4499 mL
80 mM 0.0135 mL 0.0675 mL 0.1350 mL 0.3375 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Vincristine-d3-ester sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vincristine-d3-ester1217854-24-4Leurocristine-d3-esterNSC-67574-d3-ester22-Oxovincaleukoblastine-d3-esterMicrotubule/TubulinApoptosisInhibitorinhibitorinhibit

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