2. Apoptosis
  3. Apoptosis
  4. Visilizumab

Visilizumab  (Synonyms: Anti-Human CD3E Recombinant Antibody; HuM291)

Cat. No.: HY-P99332 Purity: 98.48%
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Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research.

For research use only. We do not sell to patients.

CAS No. : 219716-33-3

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5 mg USD 1200 In-stock
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Based on 1 publication(s) in Google Scholar

Visilizumab Related Antibodies

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Description

Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research[1].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Visilizumab induces dose- and time-dependent apoptosis of lamina propria T cells. Visilizumab-induces apoptosis of lamina propria T cells is dependent on caspase 3 and 8, but not caspase 9 activation and does not involve the Fas/FasL pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Visilizumab Related Antibodies

Apoptosis Analysis[1]

Cell Line: Lamina propria T cells
Concentration: 1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL, 10000 ng/mL
Incubation Time: 2 hours, 4 hours, 20 hours, 24 hours, 48 hours
Result: Induced dose- and time-dependent apoptosis of lamina propria T cells.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Volociximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Purity & Documentation

Purity: 98.48%

SDS (251 KB)

COA (231 KB) SDS-PAGE (70 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Visilizumab Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Visilizumab219716-33-3Anti-Human CD3E Recombinant Antibody HuM291HuM291HuM 291HuM-291ApoptosisCD3low-Fc receptormonoclonal IgG2 antibodyulcerative colitisCrohn's diseaseInhibitorinhibitorinhibit

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