vMIP-II (1-21) (Synonyms: NT21MP; V1 peptide)

Cat. No.: HY-P4109: FAQs
Data Sheet Handling Instructions

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vMIP-II (1-21) (NT21MP) is an inhibitor of CXCR4. vMIP-II (1-21) interacts broadly with CC and CXC chemokine receptors. vMIP-II (1-21) inhibits CXCR4 by competing with 125I-SDF-1R for binding sites (IC₅₀=190 nM).

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vMIP-II (1-21) Chemical Structure

CAS No. : 265650-93-9

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Biological Activity
Purity & Documentation
References
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Description	vMIP-II (1-21) (NT21MP) is an inhibitor of CXCR4. vMIP-II (1-21) interacts broadly with CC and CXC chemokine receptors. vMIP-II (1-21) inhibits CXCR4 by competing with 125I-SDF-1R for binding sites (IC₅₀=190 nM)^[1].
In Vitro	vMIP-II (1-21) (0.01-10 μM) binds with CXCR4^[1]. vMIP-II (1-21) (25-200 μM) inhibits CXCR4 mediates T- and dual-tropic HIV-1 gp120-mediated cell-cell fusion^[1]. vMIP-II (1-21) (100 μM) dose-dependently inhibits the chemotactic activity^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. vMIP-II (1-21) Related Antibodies
Molecular Weight	2425.84
Formula	C₁₀₈H₁₆₉N₃₃O₂₇S
CAS No.	265650-93-9
Sequence	Leu-Gly-Ala-Ser-Trp-His-Arg-Pro-Asp-Lys-Cys-Cys-Leu-Gly-Tyr-Gln-Lys-Arg-Pro-Leu-Pro
Sequence Shortening	LGASWHRPDKCCLGYQKRPLP
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (258 KB) Handling Instructions (2659 KB)
References	[1]. Zhou N, ey al. A novel peptide antagonist of CXCR4 derived from the N-terminus of viral chemokine vMIP-II. Biochemistry. 2000 Apr 4;39(13):3782-7. [Content Brief]

vMIP-II (1-21) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

vMIP-II (1-21)265650-93-9NT21MP V1 peptideCXCRCXC chemokine receptorsC-X-C motif chemokine receptorspeptide fragmentvMIP-IIcell fusionHIV-1Inhibitorinhibitorinhibit

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