2. Apoptosis
  3. Caspase Apoptosis
  4. VMY-1-103

VMY-1-103 is an inhibitor for cyclin/Cdk complex, that arrests the cell cycle at G1 phase. VMY-1-103 reduces mitochondrial membrane potential, induces p53 phosphorylation and and PARP cleavage, activates caspase-3, and thus induces apoptosis in prostate cancer cell LNCaP.

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VMY-1-103 Chemical Structure

VMY-1-103 Chemical Structure

CAS No. : 1209002-43-6

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VMY-1-103 Related Antibodies

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Description

VMY-1-103 is an inhibitor for cyclin/Cdk complex, that arrests the cell cycle at G1 phase. VMY-1-103 reduces mitochondrial membrane potential, induces p53 phosphorylation and and PARP cleavage, activates caspase-3, and thus induces apoptosis in prostate cancer cell LNCaP[1].

Molecular Weight

708.27

Formula

C34H42ClN9O4S
CAS No.
SMILES

O=C(NCCNS(=O)(C1=C2C=CC=C(N(C)C)C2=CC=C1)=O)C3=CC=C(NC4=C5N=CN(C(C)C)C5=NC(N[C@@H](CO)C(C)C)=N4)C=C3Cl
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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VMY-1-103 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VMY-1-1031209002-43-6CaspaseApoptosisLNCaPDU145prostate cancerInhibitorinhibitorinhibit

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