1. GPCR/G Protein
  2. GCGR
  3. Volagidemab

Volagidemab  (Synonyms: REMD-477; AMG-477)

Cat. No.: HY-P99383 Purity: 98.43%
COA

Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D).

For research use only. We do not sell to patients.

CAS No. : 1233956-13-2

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1 mg USD 300 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D)[1][2].

Isotype

Human IgG2 kappa

Recommend Isotype Controls
Species

Human

In Vivo

Volagidemab (5 mg/kg, s.c.) suppresses type 1 diabetes phenotype in Alloxan-induced diabetic mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Alloxan-induced diabetic mice [2]
Dosage: 5 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Reduced phosphorylated CREB protein and PEPCK protein expression to nondiabetic levels.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Volagidemab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG2 kappa
Purity & Documentation
References
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Volagidemab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Volagidemab
Cat. No.:
HY-P99383
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