2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU6004909

VU6004909 is a blood-brain barrier penetrated mGlu1 positive allosteric modulator (PAM), with the EC50s of 25.7 nM and 31 nM for human mGlu1 and rat mGlu1, respectively. VU6004909 reduces dorsolateral striatal dopamine (DA) release in vivo and displays antipsychotic efficacy.

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VU6004909 Chemical Structure

VU6004909 Chemical Structure

CAS No. : 1860797-76-7

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10 mg USD 152 In-stock
25 mg USD 300 In-stock
50 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

VU6004909 Related Antibodies

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Description

VU6004909 is a blood-brain barrier penetrated mGlu1 positive allosteric modulator (PAM), with the EC50s of 25.7 nM and 31 nM for human mGlu1 and rat mGlu1, respectively. VU6004909 reduces dorsolateral striatal dopamine (DA) release in vivo and displays antipsychotic efficacy[1][2][3].

IC50 & Target[2][3]

Human mGluR1

25.7 nM (EC50)

rat mGluR1

31 nM (EC50)

Molecular Weight

378.35

Formula

C21H15FN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)C=CO1)NC2=CC=C(N3C(C4=CC=C(C)C=C4C3=O)=O)C=C2F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (17.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6431 mL 13.2153 mL 26.4306 mL
5 mM 0.5286 mL 2.6431 mL 5.2861 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6431 mL 13.2153 mL 26.4306 mL 66.0764 mL
5 mM 0.5286 mL 2.6431 mL 5.2861 mL 13.2153 mL
10 mM 0.2643 mL 1.3215 mL 2.6431 mL 6.6076 mL
15 mM 0.1762 mL 0.8810 mL 1.7620 mL 4.4051 mL
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VU6004909 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU60049091860797-76-7VU 6004909VU-6004909mGluRMetabotropic glutamate receptorsSchizophreniaantipsychoticMK801cognitive deficitsdopaminemuscarinic M4 receptorsInhibitorinhibitorinhibit

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