2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU6043653

VU6043653 is a potent, selective and cross the blood-brain barrier metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 value of 325 nM for h mGlu5.

For research use only. We do not sell to patients.

VU6043653 Chemical Structure

VU6043653 Chemical Structure

CAS No. : 3032791-06-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

VU6043653 Related Antibodies

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View All mGluR Isoform Specific Products:

View All Isoforms
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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Description

VU6043653 is a potent, selective and cross the blood-brain barrier metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 value of 325 nM for h mGlu5[1].

IC50 & Target[1]

human mGluR5

325 nM (IC50)

Molecular Weight

327.31

Formula

C16H14FN5O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=NC(C(NC2=CC=C(F)C=N2)=O)=CC(OC3=CN(C)N=C3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (76.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0552 mL 15.2760 mL 30.5521 mL
5 mM 0.6110 mL 3.0552 mL 6.1104 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0552 mL 15.2760 mL 30.5521 mL 76.3802 mL
5 mM 0.6110 mL 3.0552 mL 6.1104 mL 15.2760 mL
10 mM 0.3055 mL 1.5276 mL 3.0552 mL 7.6380 mL
15 mM 0.2037 mL 1.0184 mL 2.0368 mL 5.0920 mL
20 mM 0.1528 mL 0.7638 mL 1.5276 mL 3.8190 mL
25 mM 0.1222 mL 0.6110 mL 1.2221 mL 3.0552 mL
30 mM 0.1018 mL 0.5092 mL 1.0184 mL 2.5460 mL
40 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9095 mL
50 mM 0.0611 mL 0.3055 mL 0.6110 mL 1.5276 mL
60 mM 0.0509 mL 0.2546 mL 0.5092 mL 1.2730 mL
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VU6043653 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU60436533032791-06-0VU 6043653VU-6043653mGluRMetabotropic glutamate receptorsblood-brain barrierNeurological DiseaseInhibitorinhibitorinhibit

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