2. Membrane Transporter/Ion Channel
  3. EAAT
  4. WAY-213613

WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC50 value of 85 nM. WAY-213613 can be used for the research of central nervous system

For research use only. We do not sell to patients.

WAY-213613 Chemical Structure

WAY-213613 Chemical Structure

CAS No. : 868359-05-1

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of WAY-213613:

WAY-213613 Related Antibodies

Top Publications Citing Use of Products

    WAY-213613 purchased from MedChemExpress. Usage Cited in: Ann Transl Med. 2020 Jun;8(11):691.  [Abstract]

    The SAH mice are intraperitoneally administered with HDAC2 inhibitor (2 mg/kg) and GLT-1 inhibitor (WAY-213613, 1 mg/kg) two weeks after surgery once every other day. The expression of GLT-1, HDAC2, p-GluN2B and p-GluA1 in hippocampus is detected after SAH at 8 weeks.

    View All EAAT Isoform Specific Products:

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    EAAT1 EAAT2 EAAT3 EAAT4 EAAT5

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    Description

    WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC50 value of 85 nM. WAY-213613 can be used for the research of central nervous system[1][2]

    IC50 & Target

    EAAT2

     

    In Vitro

    WAY-213613 (0-100 μM) has inhibitory activity for human EAAT1, EAAT2 and EAAT3 subtype with IC50 values of 5004 nM, 85 nM and 3787 nM, respectively[1].
    WAY-213613 (3, 30, 300 nM) has the inhibitory effect on synaptosomal L-[3H] glutamate uptake with Ki values of 15 nM, 41 nM and 55 nM in the presence of 3, 30 and 300 nM, respectively[1].
    WAY-213613 (0-100 μM) produces a concentration-dependent block of glutamate-induced currents in EAAT1-, EAAT2- or EAAT3-injected oocytes, with IC50 values of 48, 0.13 and 4.0 μM, respectively[1].
    WAY-213613 (0.5–50 μM) exhibits good selectivity over ionotropic receptors and EAAT2 and potent activity toward blocking NMDA-stimulated responses[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    WAY-213613 Related Antibodies
    Molecular Weight

    415.19

    Formula

    C16H13BrF2N2O4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    BrC(C=C(F)C(F)=C1)=C1OC2=CC=C(NC(C[C@H](N)C(O)=O)=O)C=C2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (240.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4085 mL 12.0427 mL 24.0854 mL
    5 mM 0.4817 mL 2.4085 mL 4.8171 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Purity & Documentation

    Purity: ≥99.0%

    SDS (479 KB)

    COA (245 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.4085 mL 12.0427 mL 24.0854 mL 60.2134 mL
    5 mM 0.4817 mL 2.4085 mL 4.8171 mL 12.0427 mL
    10 mM 0.2409 mL 1.2043 mL 2.4085 mL 6.0213 mL
    15 mM 0.1606 mL 0.8028 mL 1.6057 mL 4.0142 mL
    20 mM 0.1204 mL 0.6021 mL 1.2043 mL 3.0107 mL
    25 mM 0.0963 mL 0.4817 mL 0.9634 mL 2.4085 mL
    30 mM 0.0803 mL 0.4014 mL 0.8028 mL 2.0071 mL
    40 mM 0.0602 mL 0.3011 mL 0.6021 mL 1.5053 mL
    50 mM 0.0482 mL 0.2409 mL 0.4817 mL 1.2043 mL
    60 mM 0.0401 mL 0.2007 mL 0.4014 mL 1.0036 mL
    80 mM 0.0301 mL 0.1505 mL 0.3011 mL 0.7527 mL
    100 mM 0.0241 mL 0.1204 mL 0.2409 mL 0.6021 mL
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    WAY-213613 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    WAY-213613868359-05-1WAY213613WAY 213613EAATExcitatory amino acid transporter Glutamate transporter| EAAT1EAAT2EAAT3central nervous systemglutamateInhibitorinhibitorinhibit

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