2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Werner syndrome RecQ helicase-IN-2

Werner syndrome RecQ helicase-IN-2 

Cat. No.: HY-148700 Purity: 99.32%
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Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research.

For research use only. We do not sell to patients.

Werner syndrome RecQ helicase-IN-2 Chemical Structure

Werner syndrome RecQ helicase-IN-2 Chemical Structure

CAS No. : 2869954-51-6

Size Price Stock Quantity
5 mg USD 580 In-stock
10 mg USD 940 In-stock
25 mg USD 1880 In-stock
50 mg USD 3000 In-stock
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Based on 1 publication(s) in Google Scholar

Werner syndrome RecQ helicase-IN-2 Related Antibodies

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Description

Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research[1].

In Vitro

Werner syndrome RecQ helicase-IN-2 (example 57) has an IC50 value of 100 nM for WRN ATPase and GI50 values of 100 nM and >10 μM for SW48 and DLD1 WRN-KO cell lines, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Werner syndrome RecQ helicase-IN-2 Related Antibodies
Molecular Weight

681.66

Formula

C32H34F3N9O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(CC1)C2=C(CC)N(CC(NC3=CC=C(C(F)(F)F)C=C3C)=O)C4=NC(C5=CCOCC5)=NN4C2=O)C6=NC=NC(C)=C6O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (73.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4670 mL 7.3350 mL 14.6701 mL
5 mM 0.2934 mL 1.4670 mL 2.9340 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4670 mL 7.3350 mL 14.6701 mL 36.6752 mL
5 mM 0.2934 mL 1.4670 mL 2.9340 mL 7.3350 mL
10 mM 0.1467 mL 0.7335 mL 1.4670 mL 3.6675 mL
15 mM 0.0978 mL 0.4890 mL 0.9780 mL 2.4450 mL
20 mM 0.0734 mL 0.3668 mL 0.7335 mL 1.8338 mL
25 mM 0.0587 mL 0.2934 mL 0.5868 mL 1.4670 mL
30 mM 0.0489 mL 0.2445 mL 0.4890 mL 1.2225 mL
40 mM 0.0367 mL 0.1834 mL 0.3668 mL 0.9169 mL
50 mM 0.0293 mL 0.1467 mL 0.2934 mL 0.7335 mL
60 mM 0.0245 mL 0.1223 mL 0.2445 mL 0.6113 mL
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Werner syndrome RecQ helicase-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Werner syndrome RecQ helicase-IN-22869954-51-6DNA/RNA SynthesisWRNcancerInhibitorinhibitorinhibit

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