Wnt/β-catenin-IN-1 

Wnt/β-catenin-in-1 (compounds 17) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors^[1].

Wnt/β-catenin-IN-1 (compounds 17) (10 μM, 48 h) has broad-spectrum anticancer activity, with an average growth inhibition rate of 81.9% against 52 tumor cell lines in the trial^[1].
Wnt/β-catenin-IN-1 (compounds 17) (10 μM, 48 h) is less cytotoxic to normal human cell lines (CCD841, MRC5) and is somewhat selective to cancer cells^[1].
Wnt/β-catenin-IN-1 (compounds 17) (0/0.5/1/2 μM, 24 h/48 h) dose-dependently triggers cell cycle arrest and increases the population of HCT116 colon cancer cells in G2/M cell cycle phase^[1].
Wnt/β-catenin-IN-1 (compounds 17) (0/0.5/1/2 μM, 24 h) is dose-dependent in reducing CDK8 level in HCT colorectal cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

463.48

C₂₆H₂₅NO₇

COC1=CC=C(C=C1)C(NC2=CC(C3CC(C4=C(C(OC)=C(C=C4O3)OC)OC)=O)=CC=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hassan AHE, et al. Discovery of a stilbenoid-flavanone hybrid as an antitumor Wnt/β-catenin signaling pathway inhibitor. Bioorg Chem. 2024 Feb 5;145:107178.  [Content Brief]