Wy-45494 hydrochloride (Synonyms: N-Desmethyl Venlafaxine hydrochloride; Wy 45494)

Cat. No.: HY-131527: FAQs
Data Sheet Handling Instructions Technical Support

Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC₅₀s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

For research use only. We do not sell to patients.

Wy-45494 hydrochloride Chemical Structure

CAS No. : 93413-90-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Wy-45494 hydrochloride:

Wy-45494 (hydrochloride) (Standard) Get quote

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Description

Molecular Weight

299.84

Formula

C₁₆H₂₆ClNO₂

CAS No.

93413-90-2

Appearance

Solid

Color

White to off-white

SMILES

OC1(C(C2=CC=C(OC)C=C2)CNC)CCCCC1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 116.67 mg/mL (389.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3351 mL	16.6756 mL	33.3511 mL
5 mM	0.6670 mL	3.3351 mL	6.6702 mL
10 mM	0.3335 mL	1.6676 mL	3.3351 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Otton, et al. Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br. J. Clin. Pharmacol. 41(2), 149-156 (1996).

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3351 mL	16.6756 mL	33.3511 mL	83.3778 mL
	5 mM	0.6670 mL	3.3351 mL	6.6702 mL	16.6756 mL
	10 mM	0.3335 mL	1.6676 mL	3.3351 mL	8.3378 mL
	15 mM	0.2223 mL	1.1117 mL	2.2234 mL	5.5585 mL
	20 mM	0.1668 mL	0.8338 mL	1.6676 mL	4.1689 mL
	25 mM	0.1334 mL	0.6670 mL	1.3340 mL	3.3351 mL
	30 mM	0.1112 mL	0.5559 mL	1.1117 mL	2.7793 mL
	40 mM	0.0834 mL	0.4169 mL	0.8338 mL	2.0844 mL
	50 mM	0.0667 mL	0.3335 mL	0.6670 mL	1.6676 mL
	60 mM	0.0556 mL	0.2779 mL	0.5559 mL	1.3896 mL
	80 mM	0.0417 mL	0.2084 mL	0.4169 mL	1.0422 mL
	100 mM	0.0334 mL	0.1668 mL	0.3335 mL	0.8338 mL

Wy-45494 hydrochloride Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Wy-4549493413-90-2N-Desmethyl Venlafaxine Wy 45494Wy45494Wy 45494Serotonin Transporter5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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Wy-45494 hydrochloride (Synonyms: N-Desmethyl Venlafaxine hydrochloride; Wy 45494)

Other Forms of Wy-45494 hydrochloride:

Wy-45494 hydrochloride Related Antibodies

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•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

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