2. Neuronal Signaling
  3. Serotonin Transporter
  4. Wy-45494 hydrochloride

Wy-45494 hydrochloride  (Synonyms: N-Desmethyl Venlafaxine hydrochloride; Wy 45494)

Cat. No.: HY-131527
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Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

For research use only. We do not sell to patients.

Wy-45494 hydrochloride Chemical Structure

Wy-45494 hydrochloride Chemical Structure

CAS No. : 93413-90-2

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Wy-45494 hydrochloride Related Antibodies

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Description

Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

Molecular Weight

299.84

Formula

C16H26ClNO2
CAS No.
SMILES

OC1(C(C2=CC=C(OC)C=C2)CNC)CCCCC1.[H]Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Wy-45494 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Wy-4549493413-90-2N-Desmethyl Venlafaxine Wy 45494Wy45494Wy 45494Serotonin Transporter5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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