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  4. XL413 hydrochloride

XL413 hydrochloride  (Synonyms: BMS-863233 hydrochloride)

Cat. No.: HY-15260C
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XL413 (BMS-863233) hydrochloride is an orally active and selective CDC7 inhibitor (IC50=3.4 nM). XL413 hydrochloride has favorable pharmacokinetic profiles and significantly inhibits tumor growth in rodent models. XL413 hydrochloride can be used in cancer research.

For research use only. We do not sell to patients.

XL413 hydrochloride Chemical Structure

XL413 hydrochloride Chemical Structure

CAS No. : 1169562-71-3

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XL413 hydrochloride Related Antibodies

Top Publications Citing Use of Products

    XL413 hydrochloride purchased from MedChemExpress. Usage Cited in: Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L360-L370.  [Abstract]

    Representative Western blot for Endo180 expression in U937 cells treated overnight with XL413.

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    CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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    Description

    XL413 (BMS-863233) hydrochloride is an orally active and selective CDC7 inhibitor (IC50=3.4 nM). XL413 hydrochloride has favorable pharmacokinetic profiles and significantly inhibits tumor growth in rodent models. XL413 hydrochloride can be used in cancer research[1].

    IC50 & Target[1]

    Cdc7

    3.4 nM (IC50)

    Formula

    C14H12ClN3O2.xHCl
    CAS No.
    SMILES

    ClC1=CC=C2C(C(N=C([C@@H]3CCCN3)NC4=O)=C4O2)=C1.Cl.[x]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    XL413 hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    XL4131169562-71-3BMS-863233XL 413XL-413BMS863233BMS 863233CDKCyclin dependent kinasecancertumorInhibitorinhibitorinhibit

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