XMT-1519 conjugate-1

Cat. No.: HY-148067: FAQs
Data Sheet SDS COA Handling Instructions

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ΧΜΤ-1519 conjugate-1 (compound 31) is a linker for the HER-2 monoclonal antibody XMT-1519, which can be used to synthesize ADC and increase anti-tumor activity.

For research use only. We do not sell to patients.

XMT-1519 conjugate-1 Chemical Structure

CAS No. : 2720500-19-4

Size	Price	Stock
1 mg	USD 2600	Ask For Quote & Lead Time
5 mg	USD 5500	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

ΧΜΤ-1519 conjugate-1 (compound 31) is a linker for the HER-2 monoclonal antibody XMT-1519, which can be used to synthesize ADC and increase anti-tumor activity^[1].

Molecular Weight

2357.39

Formula

C₁₀₁H₁₄₉N₂₃O₄₂

CAS No.

2720500-19-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(N=C(O1)C)CC)NC2=NC3=CC(C(N)=O)=CN=C3N2C/C=C/CN4C5=C(OCCCOC([C@H](C)NC(CCOCCOCCNC(CC[C@@H](C(NCC(NCC(NCC(NCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](CCC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)=O)=O)=O)=O)=O)=O)NC(CN6C(C=CC6=O)=O)=O)=O)=O)=O)C=C(C(N)=O)C=C5N=C4NC(C7=C(N=C(O7)C)CC)=O

Shipping

Shipping with dry ice.

Storage

-80°C

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (84.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4242 mL	2.1210 mL	4.2420 mL
5 mM	0.0848 mL	0.4242 mL	0.8484 mL
10 mM	0.0424 mL	0.2121 mL	0.4242 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.26%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (261 KB) HNMR (534 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Jeremy R. Duvall, et al. Antibody drug conjugates comprising sting agonists. WO2021202984 A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.4242 mL	2.1210 mL	4.2420 mL	10.6049 mL
	5 mM	0.0848 mL	0.4242 mL	0.8484 mL	2.1210 mL
	10 mM	0.0424 mL	0.2121 mL	0.4242 mL	1.0605 mL
	15 mM	0.0283 mL	0.1414 mL	0.2828 mL	0.7070 mL
	20 mM	0.0212 mL	0.1060 mL	0.2121 mL	0.5302 mL
	25 mM	0.0170 mL	0.0848 mL	0.1697 mL	0.4242 mL
	30 mM	0.0141 mL	0.0707 mL	0.1414 mL	0.3535 mL
	40 mM	0.0106 mL	0.0530 mL	0.1060 mL	0.2651 mL
	50 mM	0.0085 mL	0.0424 mL	0.0848 mL	0.2121 mL
	60 mM	0.0071 mL	0.0353 mL	0.0707 mL	0.1767 mL
	80 mM	0.0053 mL	0.0265 mL	0.0530 mL	0.1326 mL