2. GPCR/G Protein
  3. GPR35
  4. YE120

YE120 is a potent GPR35 agonist with an EC50 of 32.5 nM.

For research use only. We do not sell to patients.

YE120 Chemical Structure

YE120 Chemical Structure

CAS No. : 383124-82-1

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YE120 Related Antibodies

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Description

YE120 is a potent GPR35 agonist with an EC50 of 32.5 nM[1].

Molecular Weight

330.17

Formula

C16H9Cl2N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#C/C(C#N)=C1OC(C(C)=C/1C#N)(C)C2=CC=C(C(Cl)=C2)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 33 mg/mL (99.95 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0287 mL 15.1437 mL 30.2874 mL
5 mM 0.6057 mL 3.0287 mL 6.0575 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0287 mL 15.1437 mL 30.2874 mL 75.7186 mL
5 mM 0.6057 mL 3.0287 mL 6.0575 mL 15.1437 mL
10 mM 0.3029 mL 1.5144 mL 3.0287 mL 7.5719 mL
15 mM 0.2019 mL 1.0096 mL 2.0192 mL 5.0479 mL
20 mM 0.1514 mL 0.7572 mL 1.5144 mL 3.7859 mL
25 mM 0.1211 mL 0.6057 mL 1.2115 mL 3.0287 mL
30 mM 0.1010 mL 0.5048 mL 1.0096 mL 2.5240 mL
40 mM 0.0757 mL 0.3786 mL 0.7572 mL 1.8930 mL
50 mM 0.0606 mL 0.3029 mL 0.6057 mL 1.5144 mL
60 mM 0.0505 mL 0.2524 mL 0.5048 mL 1.2620 mL
80 mM 0.0379 mL 0.1893 mL 0.3786 mL 0.9465 mL
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YE120 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YE120383124-82-1YE 120YE-120GPR35G Protein-Coupled Receptor 35Inhibitorinhibitorinhibit

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