YE120

Cat. No.: HY-107538 Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

YE120 is a potent GPR35 agonist with an EC₅₀ of 32.5 nM.

For research use only. We do not sell to patients.

YE120 Chemical Structure

CAS No. : 383124-82-1

Size	Price	Stock
5 mg	USD 390	Ask For Quote & Lead Time
10 mg	USD 626	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

YE120 is a potent GPR35 agonist with an EC₅₀ of 32.5 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	EC₅₀	0.032 μM Compound: 1, YE120	Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay	[PMID: 21950657]
HT-29	IC₅₀	0.06 μM Compound: 1, YE120	Agonist activity at GPR35 in human HT-29 cells assessed as desensitization of 1 uM zaprinast-induced DMR after 1 hr by dynamic mass redistribution assay Agonist activity at GPR35 in human HT-29 cells assessed as desensitization of 1 uM zaprinast-induced DMR after 1 hr by dynamic mass redistribution assay	[PMID: 21950657]
U2OS	EC₅₀	10.2 μM Compound: 1, YE120	Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay	[PMID: 21950657]

Molecular Weight

330.17

Formula

C₁₆H₉Cl₂N₃O

CAS No.

383124-82-1

Appearance

Solid

Color

White to off-white

SMILES

N#C/C(C#N)=C1OC(C(C)=C/1C#N)(C)C2=CC=C(C(Cl)=C2)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 33 mg/mL (99.95 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0287 mL	15.1437 mL	30.2874 mL
5 mM	0.6057 mL	3.0287 mL	6.0575 mL
10 mM	0.3029 mL	1.5144 mL	3.0287 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (256 KB) Elemental Analysis Report (115 KB)

Handling Instructions (2659 KB)

References

[1]. Deng H, et al. Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists. J Med Chem. 2011 Oct 27;54(20):7385-96. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0287 mL	15.1437 mL	30.2874 mL	75.7186 mL
	5 mM	0.6057 mL	3.0287 mL	6.0575 mL	15.1437 mL
	10 mM	0.3029 mL	1.5144 mL	3.0287 mL	7.5719 mL
	15 mM	0.2019 mL	1.0096 mL	2.0192 mL	5.0479 mL
	20 mM	0.1514 mL	0.7572 mL	1.5144 mL	3.7859 mL
	25 mM	0.1211 mL	0.6057 mL	1.2115 mL	3.0287 mL
	30 mM	0.1010 mL	0.5048 mL	1.0096 mL	2.5240 mL
	40 mM	0.0757 mL	0.3786 mL	0.7572 mL	1.8930 mL
	50 mM	0.0606 mL	0.3029 mL	0.6057 mL	1.5144 mL
	60 mM	0.0505 mL	0.2524 mL	0.5048 mL	1.2620 mL
	80 mM	0.0379 mL	0.1893 mL	0.3786 mL	0.9465 mL

YE120 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YE120383124-82-1YE 120YE-120GPR35G Protein-Coupled Receptor 35Inhibitorinhibitorinhibit

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