2. Cell Cycle/DNA Damage
  3. CDK
  4. YJZ5118

YJZ5118 is a CDK12/13 inhibitor with IC50 values of 39.5 nM and 26.4 nM against CDK12 and CDK13, respectively. By inducing DNA damage and Apoptosis, YJZ5118 effectively suppresses tumor cell proliferation and exhibits synergistic effects with Akt inhibitors. YJZ5118 can be used for research in the field of cancer.

For research use only. We do not sell to patients.

YJZ5118 Chemical Structure

YJZ5118 Chemical Structure

CAS No. : 3031861-18-1

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YJZ5118 Related Antibodies

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Description

YJZ5118 is a CDK12/13 inhibitor with IC50 values of 39.5 nM and 26.4 nM against CDK12 and CDK13, respectively. By inducing DNA damage and Apoptosis, YJZ5118 effectively suppresses tumor cell proliferation and exhibits synergistic effects with Akt inhibitors. YJZ5118 can be used for research in the field of cancer[1].

IC50 & Target

CDK12

 

CDK13

 

Molecular Weight

620.79

Formula

C36H44N8O2
CAS No.
SMILES

C=CC(NC1=CC(N(C(NCC2=CC=CC=C2)=O)[C@H]3CC[C@@H](CC3)NC4=NC=C(C=C4)C#N)=CC=C1N5CCC(CC5)N(C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YJZ5118 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YJZ51183031861-18-1YJZ 5118YJZ-5118CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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