(Z)-Lafutidine (Synonyms: (Z)-FRG-8813)

Cat. No.: HY-121406: FAQs
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(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities.

For research use only. We do not sell to patients.

(Z)-Lafutidine Chemical Structure

CAS No. : 206449-93-6

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Other Forms of (Z)-Lafutidine:

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

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Description

(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities^[1].

In Vivo

(Z)-Lafutidine (Compound 16) stimulates mucin biosynthesis in rat gastric mucosa and this effect not directly due to histamine H2 receptor antagonism^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight- to nine-week-old male C57BL/6 mice weighing 20-24g^[1]
Dosage:	3-30 mg/kg
Administration:	P.o; twice for 6 days (5-FU: 50 mg/kg; i.p.;once daily)
Result:	Reduced the severity of diarrhea during 5-FU treatment,in a mostly dose-dependent manner, and a significant effect was observed at a dose of 30 mg/kg.

Molecular Weight

431.55

Formula

C₂₂H₂₉N₃O₄S

CAS No.

206449-93-6

SMILES

O=C(NC/C=C\COC1=NC=CC(CN2CCCCC2)=C1)CS(CC3=CC=CO3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hirakawa N, et al. A novel histamine 2(H2) receptor antagonist with gastroprotective activity. II. Synthesis and pharmacological evaluation of 2-furfuryl-thio and 2-furfurylsulfinyl acetamide derivatives with heteroaromatic rings. Chem Pharm Bull (Tokyo). [Content Brief]

(Z)-Lafutidine Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-Lafutidine206449-93-6(Z)-FRG-8813Histamine ReceptorsensoryafferentneuronsmucosalprotectivegastrointestinalInhibitorinhibitorinhibit

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