2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. Zilovertamab

Zilovertamab  (Synonyms: UC-961; Cirmtuzumab)

Cat. No.: HY-P99201 Purity: 98.20%
COA

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Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.

For research use only. We do not sell to patients.

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1 mg USD 300 In-stock
5 mg USD 850 In-stock
10 mg USD 1350 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Zilovertamab Related Antibodies

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Description

Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Zilovertamab (25 and 50 μg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation[1].
Zilovertamab (50 μg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zilovertamab Related Antibodies

Cell Proliferation Assay[1]

Cell Line: CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration: 25 and 50 µg/mL
Incubation Time: 72 hours
Result: Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.

Western Blot Analysis[1]

Cell Line: CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration: 50 µg/mL
Incubation Time: 72 hours
Result: Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.
Clinical Trial
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Zilovertamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human ROR1-ECD-His can bind Zilovertamab. The EC50 for this effect is 3.078 ng/mL.
Purity & Documentation

Purity: 98.20%

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Zilovertamab Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZilovertamabUC-961 CirmtuzumabUC961UC 961RORRAR-related orphan receptorhumanised monoclonal antibodyWnt5aROR1 signallingCaOV3Inhibitorinhibitorinhibit

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