2. Immunology/Inflammation
  3. Complement System
  4. Zilucoplan

Zilucoplan  (Synonyms: RA101495; RA3193)

Cat. No.: HY-P3502 Purity: 95.33%
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Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Zilucoplan Chemical Structure

Zilucoplan Chemical Structure

CAS No. : 1841136-73-9

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1 mg USD 550 In-stock
5 mg USD 1250 In-stock
10 mg USD 2030 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM)[1][2].

In Vitro

Zilucoplan (RA101495; 1-1000 nM; 30 min) inhibit Lipopolysaccharides-induced increase in C5a plasma levels in human whole blood with an IC50 value of 474.5 pM. Zilucoplan has a 65.7% reduction in C5a plasma levels observed at a concentration of 1 nM[2].
Zilucoplan bins to complement component 5 (C5) and blocks the downstream assembly of the membrane attack complex (MAC; C5b-9) by inhibiting the cleavage of C5 by the C5 convertase into C5a and C5b and binding to preformed C5b to sterically block interaction with C6, thereby inhibiting the formation of membrane pores and subsequent cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zilucoplan Related Antibodies
In Vivo

Zilucoplan (RA101495; 10 mg/kg; S.C.; daily, for 6 d) prevents the development of immune-mediated necrotising myopathy (IMNM) in C5-deficient mice supplemented with human complement[1].
Zilucoplan (10 mg/kg; S.C.; daily, for 6 d) has protection on myopathy prevention in C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/10SnJ C5-deficient (C5def) mice with anti-HMGCR+ IMNM IgG xenografts[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; daily, for 6 days
Result: Prevented muscle strength loss in C5def mice with less complement deposition on myofibres and consequently less necrosis/regeneration.
Animal Model: C57BL/6 mice with anti-HMGCR+ IMNM IgG xenografts[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; daily, for 6 days
Result: Prevented muscle weakness and reduced regenerated myofibres.
Decreased necrotic cells as well as regenerating cells expressing foetal myosin.
Clinical Trial
Molecular Weight

3562.18

Formula

C172H278N24O55
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (28.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2807 mL 1.4036 mL 2.8073 mL
5 mM 0.0561 mL 0.2807 mL 0.5615 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2807 mL 1.4036 mL 2.8073 mL 7.0182 mL
5 mM 0.0561 mL 0.2807 mL 0.5615 mL 1.4036 mL
10 mM 0.0281 mL 0.1404 mL 0.2807 mL 0.7018 mL
15 mM 0.0187 mL 0.0936 mL 0.1872 mL 0.4679 mL
20 mM 0.0140 mL 0.0702 mL 0.1404 mL 0.3509 mL
25 mM 0.0112 mL 0.0561 mL 0.1123 mL 0.2807 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zilucoplan1841136-73-9RA101495 RA3193RA 101495RA-101495RA3193RA 3193RA-3193Complement Systemacid macrocyclic peptideimmune-mediated necrotising myopathyC5a plasmamuscle weaknesscomplement depositionInhibitorinhibitorinhibit

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