Zimelidine

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Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant.

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Zimelidine Chemical Structure

CAS No. : 56775-88-3

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Other Forms of Zimelidine:

Zimeldine-d6 Get quote
Zimelidine dihydrochloride Get quote

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
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Description

Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant^[1]^[2]^[3]^[4].

In Vivo

Zimelidine (15 mg/kg, IP, once) reduces the development of tolerance to morphine-induced antinociception in rats^[3].
Zimelidine (5 mg/kg, IP, daily for 14 days) dose not modify the responsiveness of CA₃ hippocampal pyramidal neurons to microiontophoreticahy applied 5-HT^[2].
Zimelidine (0.2, 2 and 20 nmol/100 nL) in medial amygdaloid nucleus (MeA) evokes dose dependent hypophagic effects in fasted rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar albino rats (160-180 g, n=72)^[3]
Dosage:	15 mg/kg
Administration:	IP, once
Result:	Significantly attenuated the development and expression of morphine tolerance. The maximal antinociceptive effect of Zimelidine was obtained at the 60 minutes measurements in the zimelidine group and at the 30 minutes measurements in the morphine tolerant group by the tail-flick and hot-plate tests. Administration of zimelidine with morphine showed additive analgesic effect.

Animal Model:	Sprague-Dawley rats (150 to 250 g, Ten, male)^[2]
Dosage:	5 mg/kg
Administration:	IP, daily for 14 days
Result:	Did not modify the responsiveness of CA₃ hippocampal pyramidal neurons to microiontophoreticahy applied 5-HT.

Molecular Weight

317.22

Formula

C₁₆H₁₇BrN₂

CAS No.

56775-88-3

SMILES

CN(C/C=C(C1=CC=CN=C1)/C2=CC=C(C=C2)Br)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Heel RC, et al. Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1982 Sep;24(3):169-206. [Content Brief]

[2]. Blier P, et al. Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat. J Neurosci. 1983 Jun;3(6):1270-8. [Content Brief]

[3]. Ozdemir E, et al. Zimelidine attenuates the development of tolerance to morphine-induced antinociception. Indian J Pharmacol. 2012 Mar;44(2):215-8. [Content Brief]

[4]. Scopinho AA, et al. Medial amygdaloid nucleus 5-HT₂c receptors are involved in the hypophagic effect caused by zimelidine in rats. Neuropharmacology. 2012 Aug;63(2):301-9. [Content Brief]

Zimelidine Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zimelidine56775-88-35-HT ReceptorSerotonin TransporterSerotonin Receptor5-hydroxytryptamine Receptor5-HTTSERTSLC6A4Antidepressantserotonin reuptakeneurotransmissionInhibitorinhibitorinhibit

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