2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Serotonin Transporter
  4. Zimelidine

Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant.

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Zimelidine Chemical Structure

Zimelidine Chemical Structure

CAS No. : 56775-88-3

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Zimelidine Related Antibodies

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Description

Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant[1][2][3][4].

In Vivo

Zimelidine (15 mg/kg, IP, once) reduces the development of tolerance to morphine-induced antinociception in rats[3].
Zimelidine (5 mg/kg, IP, daily for 14 days) dose not modify the responsiveness of CA3 hippocampal pyramidal neurons to microiontophoreticahy applied 5-HT[2].
Zimelidine (0.2, 2 and 20 nmol/100 nL) in medial amygdaloid nucleus (MeA) evokes dose dependent hypophagic effects in fasted rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar albino rats (160-180 g, n=72)[3]
Dosage: 15 mg/kg
Administration: IP, once
Result: Significantly attenuated the development and expression of morphine tolerance. The maximal antinociceptive effect of Zimelidine was obtained at the 60 minutes measurements in the zimelidine group and at the 30 minutes measurements in the morphine tolerant group by the tail-flick and hot-plate tests. Administration of zimelidine with morphine showed additive analgesic effect.
Animal Model: Sprague-Dawley rats (150 to 250 g, Ten, male)[2]
Dosage: 5 mg/kg
Administration: IP, daily for 14 days
Result: Did not modify the responsiveness of CA3 hippocampal pyramidal neurons to microiontophoreticahy applied 5-HT.
Molecular Weight

317.22

Formula

C16H17BrN2
CAS No.
SMILES

CN(C/C=C(C1=CC=CN=C1)/C2=CC=C(C=C2)Br)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Zimelidine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zimelidine56775-88-35-HT ReceptorSerotonin TransporterSerotonin Receptor5-hydroxytryptamine Receptor5-HTTSERTSLC6A4Antidepressantserotonin reuptakeneurotransmissionInhibitorinhibitorinhibit

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