ZK 93423

Cat. No.: HY-116813 Purity: 99.43%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents.

For research use only. We do not sell to patients.

ZK 93423 Chemical Structure

CAS No. : 83910-44-5

Size	Price	Stock
5 mg	USD 520	Ask For Quote & Lead Time
10 mg	USD 830	Ask For Quote & Lead Time
25 mg	USD 1750	Ask For Quote & Lead Time
50 mg	USD 2800	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	CC₅₀	0.91 μM Compound: ZK-93423	Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay	10.21203/rs.3.rs-23951/v1
Caco-2	IC₅₀	1.34 μM Compound: ZK-93423	Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1

In Vivo

ZK 93423(0.3-3 mg/kg, i.p.) causes hypothermia at a dose of 3mg/kg in male mice of the B6C3F 1 strain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

390.43

Formula

C₂₃H₂₂N₂O₄

CAS No.

83910-44-5

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OCC)C1=C(C2=C(NC3=C2C=C(C=C3)OCC4=CC=CC=C4)C=N1)COC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (128.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5613 mL	12.8064 mL	25.6128 mL
5 mM	0.5123 mL	2.5613 mL	5.1226 mL
10 mM	0.2561 mL	1.2806 mL	2.5613 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.43%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (251 KB) HNMR (257 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. A H Tang, et al. Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice. Eur J Pharmacol. 1993 May 12;236(1):1-5 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5613 mL	12.8064 mL	25.6128 mL	64.0320 mL
	5 mM	0.5123 mL	2.5613 mL	5.1226 mL	12.8064 mL
	10 mM	0.2561 mL	1.2806 mL	2.5613 mL	6.4032 mL
	15 mM	0.1708 mL	0.8538 mL	1.7075 mL	4.2688 mL
	20 mM	0.1281 mL	0.6403 mL	1.2806 mL	3.2016 mL
	25 mM	0.1025 mL	0.5123 mL	1.0245 mL	2.5613 mL
	30 mM	0.0854 mL	0.4269 mL	0.8538 mL	2.1344 mL
	40 mM	0.0640 mL	0.3202 mL	0.6403 mL	1.6008 mL
	50 mM	0.0512 mL	0.2561 mL	0.5123 mL	1.2806 mL
	60 mM	0.0427 mL	0.2134 mL	0.4269 mL	1.0672 mL
	80 mM	0.0320 mL	0.1601 mL	0.3202 mL	0.8004 mL
	100 mM	0.0256 mL	0.1281 mL	0.2561 mL	0.6403 mL

ZK 93423 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZK 9342383910-44-5ZK93423ZK-93423GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAAcoolingInhibitorinhibitorinhibit

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