2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. ZK 93423

ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents.

For research use only. We do not sell to patients.

ZK 93423 Chemical Structure

ZK 93423 Chemical Structure

CAS No. : 83910-44-5

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ZK 93423 Related Antibodies

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Description

ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents[1].

In Vivo

ZK 93423(0.3-3 mg/kg, i.p.) causes hypothermia at a dose of 3mg/kg in male mice of the B6C3F 1 strain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

390.43

Formula

C23H22N2O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OCC)C1=C(C2=C(NC3=C2C=C(C=C3)OCC4=CC=CC=C4)C=N1)COC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (128.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5613 mL 12.8064 mL 25.6128 mL
5 mM 0.5123 mL 2.5613 mL 5.1226 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5613 mL 12.8064 mL 25.6128 mL 64.0320 mL
5 mM 0.5123 mL 2.5613 mL 5.1226 mL 12.8064 mL
10 mM 0.2561 mL 1.2806 mL 2.5613 mL 6.4032 mL
15 mM 0.1708 mL 0.8538 mL 1.7075 mL 4.2688 mL
20 mM 0.1281 mL 0.6403 mL 1.2806 mL 3.2016 mL
25 mM 0.1025 mL 0.5123 mL 1.0245 mL 2.5613 mL
30 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1344 mL
40 mM 0.0640 mL 0.3202 mL 0.6403 mL 1.6008 mL
50 mM 0.0512 mL 0.2561 mL 0.5123 mL 1.2806 mL
60 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0672 mL
80 mM 0.0320 mL 0.1601 mL 0.3202 mL 0.8004 mL
100 mM 0.0256 mL 0.1281 mL 0.2561 mL 0.6403 mL
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ZK 93423 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZK 9342383910-44-5ZK93423ZK-93423GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAAcoolingInhibitorinhibitorinhibit

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