2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. ZLC491

ZLC491 is an orally active CDK12/13 PROTAC degrader. ZLC491 can be used in anticancer research.

For research use only. We do not sell to patients.

ZLC491 Chemical Structure

ZLC491 Chemical Structure

CAS No. : 3053716-46-1

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ZLC491 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

ZLC491 is an orally active CDK12/13 PROTAC degrader. ZLC491 can be used in anticancer research[1].

IC50 & Target

CDK12

 

CDK13

 

Molecular Weight

866.98

Formula

C48H51FN10O5
CAS No.
SMILES

O=C(N([C@@H]1CC[C@H](CC1)NC2=CC=C(C=N2)C#N)C3=CC=C(C=C3)N4CCN(CC4)C5CCN(CC5)C6=CC7=C(C=C6F)C(N(C7=O)C8CCC(NC8=O)=O)=O)NCC9=CC=CC=C9
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZLC491 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLC4913053716-46-1ZLC 491ZLC-491PROTACsCDKCyclin dependent kinaseInhibitorinhibitorinhibit

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