2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Zolantidine dimaleate

Zolantidine dimaleate  (Synonyms: SKF 95282 dimaleate)

Cat. No.: HY-101373A Purity: 99.88%
COA Handling Instructions

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Zolantidine dimaleate (SKF 95282 dimaleate) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine dimaleate induces antinociception.

For research use only. We do not sell to patients.

Zolantidine dimaleate Chemical Structure

Zolantidine dimaleate Chemical Structure

CAS No. : 104076-39-3

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1 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

Zolantidine dimaleate Related Antibodies

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Description

Zolantidine dimaleate (SKF 95282 dimaleate) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine dimaleate induces antinociception[1][2].

IC50 & Target[1]

H2 Receptor

 

In Vivo

Zolantidine dimaleate (5, 10, 20, 40 mg/kg; s.c.) induces antinociception in cholestatic rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 200-250 g, male Wistar rats (cholestatic rats)[2]
Dosage: 5, 10, 20, 40 mg/kg
Administration: S.c.
Result: Significantly increased tail-flick latencies and induced antinociception.
Molecular Weight

613.68

Formula

C30H35N3O9S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=CC=CC=C4S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 61.36 mg/mL (99.99 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6295 mL 8.1476 mL 16.2951 mL
5 mM 0.3259 mL 1.6295 mL 3.2590 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.88%

COA (251 KB) LCMS (107 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6295 mL 8.1476 mL 16.2951 mL 40.7378 mL
5 mM 0.3259 mL 1.6295 mL 3.2590 mL 8.1476 mL
10 mM 0.1630 mL 0.8148 mL 1.6295 mL 4.0738 mL
15 mM 0.1086 mL 0.5432 mL 1.0863 mL 2.7159 mL
20 mM 0.0815 mL 0.4074 mL 0.8148 mL 2.0369 mL
25 mM 0.0652 mL 0.3259 mL 0.6518 mL 1.6295 mL
30 mM 0.0543 mL 0.2716 mL 0.5432 mL 1.3579 mL
40 mM 0.0407 mL 0.2037 mL 0.4074 mL 1.0184 mL
50 mM 0.0326 mL 0.1630 mL 0.3259 mL 0.8148 mL
60 mM 0.0272 mL 0.1358 mL 0.2716 mL 0.6790 mL
80 mM 0.0204 mL 0.1018 mL 0.2037 mL 0.5092 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Zolantidine dimaleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zolantidine dimaleate104076-39-3SKF 95282 dimaleateHistamine ReceptorInhibitorinhibitorinhibit

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