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Zolbetuximab  (Synonyms: IMAB362)

Cat. No.: HY-P99058 Purity: 96.98%
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Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors.

For research use only. We do not sell to patients.

CAS No. : 1496553-00-4

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Based on 3 publication(s) in Google Scholar

Zolbetuximab Related Antibodies

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Description

Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Chimeric
In Vitro

Zolbetuximab (0-100 μg/mL) binds to CLDN18.2+ PC cells, and induces antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zolbetuximab Related Antibodies
In Vivo

Zolbetuximab (200 μg, i.v.) alone and in combination with Gemcitabine (HY-17026) (50 mg/kg, i.p.) exhibits antitumor activity in mouse BxPC-3-CLDN18.2 xenograft models[2].
Zolbetuximab (5.7 mg/kg, i.p., three times per week for five weeks) inhibits tumor growth in SNU-620 cells xenograft model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mouse BxPC-3-CLDN18.2, MIA PaCa-2-CLDN18.2 xenograft model[2]
Dosage: 200 μg alone or with 50 mg/kg Gemcitabine
Administration: i.v.; i.p. (Gemcitabine)
Result: Inhibited tumor growth in two models, and prevented lung metastasis formation.
Prolonged survival time, and lowered fractions of CLDN18.2+ cells in MIA PaCa-2-CLDN18.2 xenograft.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Zolbetuximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 96.98%

COA (231 KB) SDS-PAGE (323 KB) SEC-HPLC (351 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Zolbetuximab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zolbetuximab1496553-00-4IMAB362IMAB 362IMAB-362OthersClaudin-18.2gastrointestinal adenocarcinomaspancreatic tumorsInhibitorinhibitorinhibit

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