α-Amylase/α-Glucosidase-IN-2

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α-Amylase/α-Glucosidase-IN-2 (compound 5) is a potent α-amylase and α-glucosidase dual inhibitor with IC₅₀ values of 13.02, 13.09 µM for α-amylase and α-glucosidase, respectively. α-Amylase/α-Glucosidase-IN-2 has the potential for the research of diabetic complications.

For research use only. We do not sell to patients.

α-Amylase/α-Glucosidase-IN-2 Chemical Structure

CAS No. : 2446063-14-3

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Description	α-Amylase/α-Glucosidase-IN-2 (compound 5) is a potent α-amylase and α-glucosidase dual inhibitor with IC₅₀ values of 13.02, 13.09 µM for α-amylase and α-glucosidase, respectively. α-Amylase/α-Glucosidase-IN-2 has the potential for the research of diabetic complications^[1].
IC₅₀ & Target	IC₅₀: 13.02 µM (α-amylase); 13.09 µM (α-glucosidase)^[1].
Molecular Weight	385.85
Formula	C₂₂H₁₆ClN₅
CAS No.	2446063-14-3
SMILES	ClC1=CC=C(C=C1)/C=N/NC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=N2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Shamim S, et al. Synthesis and screening of (E)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs as novel dual inhibitors of α-amylase and α-glucosidase. Bioorg Chem. 2020 Aug;101:103979. [Content Brief]