2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. α-Casozepine

α-Casozepine is a bioactive peptide derived from the α protein S1 casein in milk and has an affinity for γ-aminobutyric acid (GABA) receptors in the brain. α-Casozepine has anti-anxiety effects.

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α-Casozepine Chemical Structure

α-Casozepine Chemical Structure

CAS No. : 117592-45-7

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Based on 1 publication(s) in Google Scholar

α-Casozepine Related Antibodies

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Description

α-Casozepine is a bioactive peptide derived from the α protein S1 casein in milk and has an affinity for γ-aminobutyric acid (GABA) receptors in the brain. α-Casozepine has anti-anxiety effects[1][2].

Molecular Weight

1267.47

Formula

C60H94N14O16
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Leu-Gly-Tyr-Leu-Glu-Gln-Leu-Leu-Arg
Sequence Shortening

YLGYLEQLLR
SMILES

OC(C=C1)=CC=C1C[C@H](NC(CNC([C@H](CC(C)C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 66.67 mg/mL (52.60 mM; ultrasonic and adjust pH to 2 with 1 M HCL)

DMSO : 20 mg/mL (15.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7890 mL 3.9449 mL 7.8897 mL
5 mM 0.1578 mL 0.7890 mL 1.5779 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.36%

SDS (252 KB)

COA (247 KB) RP-HPLC (390 KB) MS (123 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.7890 mL 3.9449 mL 7.8897 mL 19.7243 mL
5 mM 0.1578 mL 0.7890 mL 1.5779 mL 3.9449 mL
10 mM 0.0789 mL 0.3945 mL 0.7890 mL 1.9724 mL
15 mM 0.0526 mL 0.2630 mL 0.5260 mL 1.3150 mL
H2O 20 mM 0.0394 mL 0.1972 mL 0.3945 mL 0.9862 mL
25 mM 0.0316 mL 0.1578 mL 0.3156 mL 0.7890 mL
30 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6575 mL
40 mM 0.0197 mL 0.0986 mL 0.1972 mL 0.4931 mL
50 mM 0.0158 mL 0.0789 mL 0.1578 mL 0.3945 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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α-Casozepine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Casozepine117592-45-7GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAAntianxietybenzodiazepineInhibitorinhibitorinhibit

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