2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. α-Glucosidase-IN-16

α-Glucosidase-IN-16 is a potent and orally active α-glucosidase inhibitor with an IC50 value of 3.28 μM. α-Glucosidase-IN-16 can reduce the level of blood glucose in Streptozotocin-induced diabetic rats. Antidiabetic activity.

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α-Glucosidase-IN-16 Chemical Structure

α-Glucosidase-IN-16 Chemical Structure

CAS No. : 1606142-34-0

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α-Glucosidase-IN-16 Related Antibodies

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Description

α-Glucosidase-IN-16 is a potent and orally active α-glucosidase inhibitor with an IC50 value of 3.28 μM. α-Glucosidase-IN-16 can reduce the level of blood glucose in Streptozotocin-induced diabetic rats. Antidiabetic activity[1].

IC50 & Target

IC50: 3.28 μM (α-Glucosidase)[1]
In Vivo

α-Glucosidase-IN-16 (compound 13B) (10 and 20 mg/kg; PO; once daily for 28 days) significantly reduces the level of blood glucose in diabetic rats[1].
α-Glucosidase-IN-16 (2000 mg/kg; PO; single dosage) exhibits no toxic effects in mice[1].
α-Glucosidase-IN-16 (10 and 20 mg/kg; PO; single dosage) significantly reduces serum glucose level after glucose administration in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (170-200 g, 8-10 weeks; induced diabetes by intraperitoneal injection of Streptozotocin (HY-13753))[1]
Dosage: 10 and 20 mg/kg
Administration: PO; once daily for 28 days
Result: Caused a significant reduction in the level of blood glucose compared to diabetic control.
Lowered the total cholesterol level.
Effect of α-Glucosidase-IN-16 on blood glucose (mg/dL) in Streptozotocin-induced diabetes[1].
dose (mg/kg) day 1 day 7 day 14 day 21 day 28
10 370.81 ± 4.79 289.89 ± 4.33 200.33 ± 4.57 149.30 ± 4.56 132.98 ± 4.33
20 375.31 ± 5.01 230.71 ± 4.88 163.68 ± 4.37 120.72 ± 4.11 108.42 ± 3.98
Animal Model: Balb/C mice[1]
Dosage: 2000 mg/kg
Administration: PO; single dosage (acute toxicity study)
Result: Exhibited no toxic effects (via observing signs of diarrhea, convulsions, lethargy, sleeping, salivation, and tremor).
Animal Model: Wistar rats (oral administration with 3 g/kg glucose)[1]
Dosage: 10 and 20 mg/kg
Administration: PO; single dosage (oral glucose tolerance test)
Result: Significantly reduced serum glucose level (110-113 mg/dL) compared to the control group (128 mg/dL) after 2 hours of glucose administration.
Molecular Weight

347.45

Formula

C22H18FNS
CAS No.
SMILES

CC1=CC=C(C2=NC3=CC=CC=C3SC(C4=CC=C(F)C=C4)C2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α-Glucosidase-IN-16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-161606142-34-0Glucosidaseorally activediabetesblood glucoseserum glucoseantidiabeticStreptozotocinWistar ratsBalb/C miceInhibitorinhibitorinhibit

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