2. GPCR/G Protein
  3. CRFR
  4. α-Helical CRF(9-41)

α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM.

For research use only. We do not sell to patients.

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α-Helical CRF(9-41) Chemical Structure

α-Helical CRF(9-41) Chemical Structure

CAS No. : 90880-23-2

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1 mg USD 110 In-stock
5 mg USD 260 In-stock
10 mg USD 410 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of α-Helical CRF(9-41):

α-Helical CRF(9-41) Related Antibodies

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Description

α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].

IC50 & Target

KB: ~100 nM (CRF2 receptor)[2]
EC50: 140 nM (CRF1 receptor)[2]
Molecular Weight

3826.40

Formula

C166H274N46O53S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (13.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2613 mL 1.3067 mL 2.6134 mL
5 mM 0.0523 mL 0.2613 mL 0.5227 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2613 mL 1.3067 mL 2.6134 mL 6.5336 mL
5 mM 0.0523 mL 0.2613 mL 0.5227 mL 1.3067 mL
10 mM 0.0261 mL 0.1307 mL 0.2613 mL 0.6534 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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α-Helical CRF(9-41) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Helical CRF(9-41)90880-23-2CRFRCorticotropin-releasing Factor ReceptorCRHRCRF2CRF1anxiogeniccompetitiveInhibitorinhibitorinhibit

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