2. Epigenetics Metabolic Enzyme/Protease
  3. Histone Demethylase Endogenous Metabolite
  4. α-Hydroxyglutaric acid-13C5 disodium

α-Hydroxyglutaric acid-13C5 disodium  (Synonyms: 2-Hydroxyglutarate-13C5 disodium; 2-Hydroxyglutaric acid-13C5 sodium; 2-Hydroxypentanedioic acid-13C5 disodium)

Cat. No.: HY-113038AS Purity: 99.80%
SDS COA Handling Instructions

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α-Hydroxyglutaric acid-13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

For research use only. We do not sell to patients.

α-Hydroxyglutaric acid-<sup>13</sup>C<sub>5</sub> disodium Chemical Structure

α-Hydroxyglutaric acid-13C5 disodium Chemical Structure

CAS No. : 2482467-23-0

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Based on 1 publication(s) in Google Scholar

Other Forms of α-Hydroxyglutaric acid-13C5 disodium:

α-Hydroxyglutaric acid-13C5 disodium Related Antibodies

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Description

α-Hydroxyglutaric acid-13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Hydroxyglutaric acid-13C5 disodium Related Antibodies
Molecular Weight

197.04

Formula

13C5H6Na2O5
CAS No.
Unlabeled CAS

40951-21-1
Appearance

Solid

Color

White to off-white

SMILES

O=[13C](O[Na])[13CH2][13CH2][13CH](O)[13C](O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (634.39 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0751 mL 25.3756 mL 50.7511 mL
5 mM 1.0150 mL 5.0751 mL 10.1502 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.80%

SDS (252 KB)

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0751 mL 25.3756 mL 50.7511 mL 126.8778 mL
5 mM 1.0150 mL 5.0751 mL 10.1502 mL 25.3756 mL
10 mM 0.5075 mL 2.5376 mL 5.0751 mL 12.6878 mL
15 mM 0.3383 mL 1.6917 mL 3.3834 mL 8.4585 mL
20 mM 0.2538 mL 1.2688 mL 2.5376 mL 6.3439 mL
25 mM 0.2030 mL 1.0150 mL 2.0300 mL 5.0751 mL
30 mM 0.1692 mL 0.8459 mL 1.6917 mL 4.2293 mL
40 mM 0.1269 mL 0.6344 mL 1.2688 mL 3.1719 mL
50 mM 0.1015 mL 0.5075 mL 1.0150 mL 2.5376 mL
60 mM 0.0846 mL 0.4229 mL 0.8459 mL 2.1146 mL
80 mM 0.0634 mL 0.3172 mL 0.6344 mL 1.5860 mL
100 mM 0.0508 mL 0.2538 mL 0.5075 mL 1.2688 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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α-Hydroxyglutaric acid-13C5 disodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Hydroxyglutaric acid-13C5 disodium2482467-23-02-Hydroxyglutarate-13C5 disodium2-Hydroxyglutaric acid-13C52-Hydroxypentanedioic acid-13C5 disodiumHistone DemethylaseEndogenous MetaboliteInhibitorinhibitorinhibit

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