2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. α,β-Methylene-ATP trisodium

α,β-Methylene-ATP trisodium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene-ATP trisodium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7.

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α,β-Methylene-ATP trisodium Chemical Structure

α,β-Methylene-ATP trisodium Chemical Structure

CAS No. : 1343364-54-4

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Based on 1 publication(s) in Google Scholar

Other Forms of α,β-Methylene-ATP trisodium:

α,β-Methylene-ATP trisodium Related Antibodies

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Description

α,β-Methylene-ATP trisodium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand[1]. α,β-Methylene-ATP trisodium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[2].

IC50 & Target

p2x1 Receptor

 

P2X3 Receptor

 

P2X7 Receptor

 

Molecular Weight

571.15

Formula

C11H15N5Na3O12P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)([O])OP(CP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O[Na])=O)(O[Na])=O.[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (218.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7509 mL 8.7543 mL 17.5085 mL
5 mM 0.3502 mL 1.7509 mL 3.5017 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.75%

COA (256 KB) HNMR (271 KB) RP-HPLC (223 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7509 mL 8.7543 mL 17.5085 mL 43.7713 mL
5 mM 0.3502 mL 1.7509 mL 3.5017 mL 8.7543 mL
10 mM 0.1751 mL 0.8754 mL 1.7509 mL 4.3771 mL
15 mM 0.1167 mL 0.5836 mL 1.1672 mL 2.9181 mL
20 mM 0.0875 mL 0.4377 mL 0.8754 mL 2.1886 mL
25 mM 0.0700 mL 0.3502 mL 0.7003 mL 1.7509 mL
30 mM 0.0584 mL 0.2918 mL 0.5836 mL 1.4590 mL
40 mM 0.0438 mL 0.2189 mL 0.4377 mL 1.0943 mL
50 mM 0.0350 mL 0.1751 mL 0.3502 mL 0.8754 mL
60 mM 0.0292 mL 0.1459 mL 0.2918 mL 0.7295 mL
80 mM 0.0219 mL 0.1094 mL 0.2189 mL 0.5471 mL
100 mM 0.0175 mL 0.0875 mL 0.1751 mL 0.4377 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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α,β-Methylene-ATP trisodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α,β-Methylene-ATP trisodium1343364-54-4P2X ReceptorP2XRsInhibitorinhibitorinhibit

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