α,β-Methylene-ATP trisodium

Name: α,β-Methylene-ATP trisodium
Brand: MedChemExpress
SKU: HY-108652
Rating: 4.5 (1 reviews)

Cat. No.: HY-108652 Purity: 99.75%: FAQs
Data Sheet SDS COA Handling Instructions

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α,β-Methylene-ATP trisodium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene-ATP trisodium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7.

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α,β-Methylene-ATP trisodium Chemical Structure

CAS No. : 1343364-54-4

Size	Price	Stock	Quantity
5 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 235	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of α,β-Methylene-ATP trisodium:

α,β-Methylene-ATP dilithium Get quote
α,β-Methylene-ATP Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

α,β-Methylene-ATP trisodium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand^[1]. α,β-Methylene-ATP trisodium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7^[2].

IC₅₀ & Target

p2x1 Receptor

P2X3 Receptor

P2X7 Receptor

Molecular Weight

571.15

Formula

C₁₁H₁₅N₅Na₃O₁₂P₃

CAS No.

1343364-54-4

Appearance

Solid

Color

White to off-white

SMILES

O=P(O)([O])OP(CP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O[Na])=O)(O[Na])=O.[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (218.86 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7509 mL	8.7543 mL	17.5085 mL
5 mM	0.3502 mL	1.7509 mL	3.5017 mL
10 mM	0.1751 mL	0.8754 mL	1.7509 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.75%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (256 KB) HNMR (271 KB) RP-HPLC (223 KB)

Handling Instructions (2659 KB)

References

[1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1). [Content Brief]

[2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7509 mL	8.7543 mL	17.5085 mL	43.7713 mL
	5 mM	0.3502 mL	1.7509 mL	3.5017 mL	8.7543 mL
	10 mM	0.1751 mL	0.8754 mL	1.7509 mL	4.3771 mL
	15 mM	0.1167 mL	0.5836 mL	1.1672 mL	2.9181 mL
	20 mM	0.0875 mL	0.4377 mL	0.8754 mL	2.1886 mL
	25 mM	0.0700 mL	0.3502 mL	0.7003 mL	1.7509 mL
	30 mM	0.0584 mL	0.2918 mL	0.5836 mL	1.4590 mL
	40 mM	0.0438 mL	0.2189 mL	0.4377 mL	1.0943 mL
	50 mM	0.0350 mL	0.1751 mL	0.3502 mL	0.8754 mL
	60 mM	0.0292 mL	0.1459 mL	0.2918 mL	0.7295 mL
	80 mM	0.0219 mL	0.1094 mL	0.2189 mL	0.5471 mL
	100 mM	0.0175 mL	0.0875 mL	0.1751 mL	0.4377 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.