2. Cytoskeleton
  3. Integrin
  4. α4 integrin receptor antagonist 3

α4 integrin receptor antagonist 3 (Compound 11) is an orally active α4integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model.

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α4 integrin receptor antagonist 3 Chemical Structure

α4 integrin receptor antagonist 3 Chemical Structure

CAS No. : 863226-74-8

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α4 integrin receptor antagonist 3 Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

α4 integrin receptor antagonist 3 (Compound 11) is an orally active α4integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model[1].
IC50 & Target

α4β1

 

α4β7

 

In Vitro

α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α4 integrin receptor antagonist 3 Related Antibodies
Molecular Weight

506.34

Formula

C23H21Cl2N3O6
CAS No.
SMILES

COC1=C(C2=CC=C(C=C2)C[C@@H](C(O)=O)NC(C3=C(C=CC=C3Cl)Cl)=O)C(N(N=C1)CCO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α4 integrin receptor antagonist 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α4 integrin receptor antagonist 3863226-74-8Integrinorally activecell adhesioncolitisInhibitorinhibitorinhibit

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