2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. α5IA

α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential.

For research use only. We do not sell to patients.

α5IA Chemical Structure

α5IA Chemical Structure

CAS No. : 215874-86-5

Size Price Stock Quantity
1 mg USD 80 In-stock
5 mg USD 160 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

α5IA Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1].

In Vitro

α5IA (100 nM, 5 days) can significantly reduce Aβ 1-42-induced cell death in primary mouse hippocampal cultures[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α5IA Related Antibodies

Cell Viability Assay[1]

Cell Line: Primary mouse hippocampal culture
Concentration: 0.3 nM, 3 nM, 30 nM, 100 nM
Incubation Time: 24 h
Result: Significantly reduced Aβ 1-42-induced cell death by 13% at a concentration of 100 nM.
Significantly decreased the expression of GABAAR α5 subunit.
In Vivo

α5IA (5 mg/kg, i.p., once) can sustain restoration of spatial learning ability in Ts65Dn mice, and long-term recognition of spatial memory deficits[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

362.35

Formula

C17H14N8O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1N=NC(COC(C2=C3C=CC=C2)=NN4C3=NN=C4C5=NOC(C)=C5)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (2.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7598 mL 13.7988 mL 27.5976 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.33%

COA (251 KB) HNMR (247 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7598 mL 13.7988 mL 27.5976 mL 68.9941 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

α5IA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α5IA215874-86-5L-822179L822179L 822179GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAAα5neuroprotectiveInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
α5IA
Cat. No.:
HY-116622
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.