β-Amyrenonol  (Synonyms: 11-Oxo-β-amyrin)

β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids^[1][2].

β-Amyrenonol (11-Oxo-β-amyrin) inhibits cell growth of HL60 cells with an IC₅₀ value of 26.3 μM^[1].
β-Amyrenonol (11-Oxo-β-amyrin) (100 μM) significantly reduces lipopolysaccharide-induced TNFα release in THP-1 cells^[1].
CYP88D6 is characterized by in vitro enzymatic activity assays and shown to catalyze the sequential two-step oxidation of β-amyrin at C-11 to produce β-Amyrenonol (11-Oxo-β-amyrin). CYP88D6 coexpressed with β-amyrin synthase in yeast also catalyzed in vivo oxidation of β-amyrin to β-Amyrenonol^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

440.70

C₃₀H₄₈O₂

38242-02-3

C[C@@]1([C@@]2([H])[C@@]3([C@@](C(C)([C@@H](O)CC3)C)([H])CC1)C)[C@]4(C([C@@]5([H])[C@](C)(CCC(C)(C)C5)CC4)=CC2=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. James Reed, et al. A Translational Synthetic Biology Platform for Rapid Access to Gram-Scale Quantities of Novel Drug-Like Molecules. Metab Eng. 2017 Jul;42:185-193.  [Content Brief]

  [2]. Ming Zhu, et al. Boosting 11-oxo-β-amyrin and Glycyrrhetinic Acid Synthesis in Saccharomyces Cerevisiae via Pairing Novel Oxidation and Reduction System From Legume Plants. Metab Eng. 2018 Jan;45:43-50.  [Content Brief]

  [3]. Hikaru Seki, et al. Licorice Beta-Amyrin 11-oxidase, a Cytochrome P450 With a Key Role in the Biosynthesis of the Triterpene Sweetener Glycyrrhizin. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14204-9.  [Content Brief]