2. Stem Cell/Wnt
  3. β-catenin
  4. β-catenin-IN-6

β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model.

For research use only. We do not sell to patients.

β-catenin-IN-6 Chemical Structure

β-catenin-IN-6 Chemical Structure

CAS No. : 1039731-99-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1272 In-stock
Solution
10 mM * 1 mL in DMSO USD 1272 In-stock
Solid
1 mg USD 552 In-stock
5 mg USD 1380 In-stock
10 mg USD 2200 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

β-catenin-IN-6 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model[1][2].

Cellular Effect
Cell Line Type Value Description References
DLD-1 IC50
1739 nM
Compound: 9
Growth inhibition of human DLD1 cells after 3 days by luminescent cell viability assay
Growth inhibition of human DLD1 cells after 3 days by luminescent cell viability assay
[PMID: 20025292]
HT-29 IC50
1375 nM
Compound: 9
Growth inhibition of human HT-29 cells after 3 days by luminescent cell viability assay
Growth inhibition of human HT-29 cells after 3 days by luminescent cell viability assay
[PMID: 20025292]
LoVo IC50
1400 nM
Compound: 9
Growth inhibition of human LoVo cells after 3 days by luminescent cell viability assay
Growth inhibition of human LoVo cells after 3 days by luminescent cell viability assay
[PMID: 20025292]
In Vitro

β-catenin-IN-6 (compound 9) (24 h) inhibits in LoVo and HT29 cells with IC50s of 1.4 μM and 1.37 μM, respectively. β-catenin-IN-6 shows cell growth inhibition against several human colorectal cancer lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-catenin-IN-6 Related Antibodies
In Vivo

β-catenin-IN-6 (compound 9) displays poor bioavailability[1].
β-catenin-IN-6 (18.75 mg/kg; ip; once daily for 7 days) decreases tumor volume in mouse model, without affecting body weight[1].
β-catenin-IN-6 (compound 13) (150 mg/kg; ip; once per week) suppresses xenograft tumor growth in a β-catenin/RK3E mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice bearing subcutaneous β-catenin/ RK3E tumors[1][2]
Dosage: 18.75 mg/kg, 37.5 mg/kg, 75.1 mg/kg, 150 mg/kg
Administration: IP; once daily for 7 days
Result: Inhibited tumor growth up to 66% in mouse model.
Showed dose-dependently inhibition on tumor growth and volume.
Molecular Weight

418.88

Formula

C22H19ClN6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN=C(C=C1)Cl)NC2=CC=C(CNC3=C4C=CC=CC4=NC(NC)=N3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (238.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3873 mL 11.9366 mL 23.8732 mL
5 mM 0.4775 mL 2.3873 mL 4.7746 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3873 mL 11.9366 mL 23.8732 mL 59.6830 mL
5 mM 0.4775 mL 2.3873 mL 4.7746 mL 11.9366 mL
10 mM 0.2387 mL 1.1937 mL 2.3873 mL 5.9683 mL
15 mM 0.1592 mL 0.7958 mL 1.5915 mL 3.9789 mL
20 mM 0.1194 mL 0.5968 mL 1.1937 mL 2.9841 mL
25 mM 0.0955 mL 0.4775 mL 0.9549 mL 2.3873 mL
30 mM 0.0796 mL 0.3979 mL 0.7958 mL 1.9894 mL
40 mM 0.0597 mL 0.2984 mL 0.5968 mL 1.4921 mL
50 mM 0.0477 mL 0.2387 mL 0.4775 mL 1.1937 mL
60 mM 0.0398 mL 0.1989 mL 0.3979 mL 0.9947 mL
80 mM 0.0298 mL 0.1492 mL 0.2984 mL 0.7460 mL
100 mM 0.0239 mL 0.1194 mL 0.2387 mL 0.5968 mL
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β-catenin-IN-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-catenin-IN-61039731-99-1β-cateninBeta cateninInhibitorinhibitorinhibit

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