β-D-glucuronide-pNP-carbonate

Name: β-D-glucuronide-pNP-carbonate
Brand: MedChemExpress
SKU: HY-136329
Rating: 4.5 (1 reviews)

Cat. No.: HY-136329 Purity: 99.44%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

β-D-glucuronide-pNP-carbonate Chemical Structure

CAS No. : 894095-98-8

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
50 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 914	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Glycosidase Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

913.83

Formula

C₄₅H₄₃N₃O₁₈

CAS No.

894095-98-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCC(NC(C=C1COC(OC(C=C2)=CC=C2[N+]([O-])=O)=O)=C(C=C1)O[C@H](O[C@@H]3C(OC)=O)[C@@H]([C@H]([C@@H]3OC(C)=O)OC(C)=O)OC(C)=O)=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 140 mg/mL (153.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0943 mL	5.4715 mL	10.9430 mL
5 mM	0.2189 mL	1.0943 mL	2.1886 mL
10 mM	0.1094 mL	0.5471 mL	1.0943 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.44%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (253 KB) HNMR (339 KB) RP-HPLC (243 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0943 mL	5.4715 mL	10.9430 mL	27.3574 mL
	5 mM	0.2189 mL	1.0943 mL	2.1886 mL	5.4715 mL
	10 mM	0.1094 mL	0.5471 mL	1.0943 mL	2.7357 mL
	15 mM	0.0730 mL	0.3648 mL	0.7295 mL	1.8238 mL
	20 mM	0.0547 mL	0.2736 mL	0.5471 mL	1.3679 mL
	25 mM	0.0438 mL	0.2189 mL	0.4377 mL	1.0943 mL
	30 mM	0.0365 mL	0.1824 mL	0.3648 mL	0.9119 mL
	40 mM	0.0274 mL	0.1368 mL	0.2736 mL	0.6839 mL
	50 mM	0.0219 mL	0.1094 mL	0.2189 mL	0.5471 mL
	60 mM	0.0182 mL	0.0912 mL	0.1824 mL	0.4560 mL
	80 mM	0.0137 mL	0.0684 mL	0.1368 mL	0.3420 mL
	100 mM	0.0109 mL	0.0547 mL	0.1094 mL	0.2736 mL