2. Neuronal Signaling
  3. Beta-secretase
  4. β-Secretase Inhibitor I

β-Secretase Inhibitor I is an extremely potent β-secretase inhibitor with reduced cardiovascular and liver toxicity.

For research use only. We do not sell to patients.

β-Secretase Inhibitor I Chemical Structure

β-Secretase Inhibitor I Chemical Structure

CAS No. : 1818239-19-8

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β-Secretase Inhibitor I Related Antibodies

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Description

β-Secretase Inhibitor I is an extremely potent β-secretase inhibitor with reduced cardiovascular and liver toxicity.

Cellular Effect
Cell Line Type Value Description References
SH-SY5Y IC50
0.38 nM
Compound: 5
Inhibition of BACE1 in human SH-SY5Y cells expressing human wild type amyloid precursor protein assessed as reduction in amyloidbeta40 production incubated for 24 hrs by HTRF assay
Inhibition of BACE1 in human SH-SY5Y cells expressing human wild type amyloid precursor protein assessed as reduction in amyloidbeta40 production incubated for 24 hrs by HTRF assay
[PMID: 31549838]
Molecular Weight

425.43

Formula

C18H18F3N5O2S
CAS No.
SMILES

O=C(C1=NC=C(OCF)N=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)S[C@H](C)[C@@H]3F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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β-Secretase Inhibitor I Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Secretase Inhibitor I1818239-19-8Beta-secretaseBACEβ-SecretaseInhibitorinhibitorinhibit

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β-Secretase Inhibitor I
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HY-126548
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