2. Others Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds GABA Receptor Endogenous Metabolite
  4. γ-Aminobutyric acid-d2

γ-Aminobutyric acid-d2  (Synonyms: 4-Aminobutyric acid-d2)

Cat. No.: HY-N0067S1 Purity: 99.72%
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γ-Aminobutyric acid-d2 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].

For research use only. We do not sell to patients.

γ-Aminobutyric acid-d<sub>2</sub> Chemical Structure

γ-Aminobutyric acid-d2 Chemical Structure

CAS No. : 67910-98-9

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Based on 1 publication(s) in Google Scholar

Other Forms of γ-Aminobutyric acid-d2:

γ-Aminobutyric acid-d2 Related Antibodies

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Description

γ-Aminobutyric acid-d2 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Aminobutyric acid-d2 Related Antibodies
Molecular Weight

105.13

Formula

C4H7D2NO2
CAS No.
Unlabeled CAS

56-12-2
Appearance

Solid

Color

White to off-white

SMILES

[2H]C(CCN)([2H])C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (475.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.5120 mL 47.5602 mL 95.1203 mL
5 mM 1.9024 mL 9.5120 mL 19.0241 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.5120 mL 47.5602 mL 95.1203 mL 237.8008 mL
5 mM 1.9024 mL 9.5120 mL 19.0241 mL 47.5602 mL
10 mM 0.9512 mL 4.7560 mL 9.5120 mL 23.7801 mL
15 mM 0.6341 mL 3.1707 mL 6.3414 mL 15.8534 mL
20 mM 0.4756 mL 2.3780 mL 4.7560 mL 11.8900 mL
25 mM 0.3805 mL 1.9024 mL 3.8048 mL 9.5120 mL
30 mM 0.3171 mL 1.5853 mL 3.1707 mL 7.9267 mL
40 mM 0.2378 mL 1.1890 mL 2.3780 mL 5.9450 mL
50 mM 0.1902 mL 0.9512 mL 1.9024 mL 4.7560 mL
60 mM 0.1585 mL 0.7927 mL 1.5853 mL 3.9633 mL
80 mM 0.1189 mL 0.5945 mL 1.1890 mL 2.9725 mL
100 mM 0.0951 mL 0.4756 mL 0.9512 mL 2.3780 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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γ-Aminobutyric acid-d2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Aminobutyric acid-d267910-98-94-Aminobutyric acid-d2Isotope-Labeled CompoundsGABA ReceptorEndogenous MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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