γ-Tocopherol-d₄

Name: γ-Tocopherol-d 4
Brand: MedChemExpress
SKU: HY-N7148S1
Rating: 5.0 (1 reviews)

Cat. No.: HY-N7148S1 Purity: 98.90%: FAQs
Data Sheet SDS COA Handling Instructions

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γ-Tocopherol-d₄ is the deuterium labeled γ-Tocopherol. γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity[1][2].

For research use only. We do not sell to patients.

γ-Tocopherol-d<sub>4</sub> Chemical Structure

γ-Tocopherol-d₄ Chemical Structure

CAS No. : 1329652-13-2

Size	Price	Stock	Quantity
1 mg	USD 675	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1860	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2980	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of γ-Tocopherol-d₄:

γ-Tocopherol Get quote

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•Related Small Molecules:

•Related Proteins:

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COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

420.70

Formula

C₂₈H₄₄D₄O₂

CAS No.

1329652-13-2

Unlabeled CAS

54-28-4

Appearance

Oil

Color

Colorless to light yellow

SMILES

CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C([2H])C(O)=C1C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (237.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3770 mL	11.8850 mL	23.7699 mL
5 mM	0.4754 mL	2.3770 mL	4.7540 mL
10 mM	0.2377 mL	1.1885 mL	2.3770 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.90%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (243 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Q Jiang, et al. Gamma-Tocopherol, the Major Form of Vitamin E in the US Diet, Deserves More Attention. Am J Clin Nutr. 2001 Dec;74(6):714-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3770 mL	11.8850 mL	23.7699 mL	59.4248 mL
	5 mM	0.4754 mL	2.3770 mL	4.7540 mL	11.8850 mL
	10 mM	0.2377 mL	1.1885 mL	2.3770 mL	5.9425 mL
	15 mM	0.1585 mL	0.7923 mL	1.5847 mL	3.9617 mL
	20 mM	0.1188 mL	0.5942 mL	1.1885 mL	2.9712 mL
	25 mM	0.0951 mL	0.4754 mL	0.9508 mL	2.3770 mL
	30 mM	0.0792 mL	0.3962 mL	0.7923 mL	1.9808 mL
	40 mM	0.0594 mL	0.2971 mL	0.5942 mL	1.4856 mL
	50 mM	0.0475 mL	0.2377 mL	0.4754 mL	1.1885 mL
	60 mM	0.0396 mL	0.1981 mL	0.3962 mL	0.9904 mL
	80 mM	0.0297 mL	0.1486 mL	0.2971 mL	0.7428 mL
	100 mM	0.0238 mL	0.1188 mL	0.2377 mL	0.5942 mL