2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. ω-Hydroxy-DEET

ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes.

For research use only. We do not sell to patients.

ω-Hydroxy-DEET Chemical Structure

ω-Hydroxy-DEET Chemical Structure

CAS No. : 72236-22-7

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Based on 1 publication(s) in Google Scholar

ω-Hydroxy-DEET Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes[1][2][3].

In Vitro

Hepatoma cell studies reveals that ω-Hydroxy-DEET (DHMB; 0.1-10 μg/mL; 48-72 hours) treatments decreases cellular proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ω-Hydroxy-DEET Related Antibodies
In Vivo

The metabolite ω-Hydroxy-DEET (DHMB) is extensively distributed following intravenous and topical skin administration of DEET in rats. The ω-Hydroxy-DEET appeared to be the major metabolite for DEET. Repeated once-daily topical application for 30 days lead to higher concentrations of ω-Hydroxy-DEET in the liver[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

207.27

Formula

C12H17NO2
CAS No.
Appearance

Liquid (Density: 1.082±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(N(CC)CC)C1=CC=CC(CO)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (482.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8246 mL 24.1231 mL 48.2462 mL
5 mM 0.9649 mL 4.8246 mL 9.6493 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8246 mL 24.1231 mL 48.2462 mL 120.6156 mL
5 mM 0.9649 mL 4.8246 mL 9.6492 mL 24.1231 mL
10 mM 0.4825 mL 2.4123 mL 4.8246 mL 12.0616 mL
15 mM 0.3216 mL 1.6082 mL 3.2164 mL 8.0410 mL
20 mM 0.2412 mL 1.2062 mL 2.4123 mL 6.0308 mL
25 mM 0.1930 mL 0.9649 mL 1.9298 mL 4.8246 mL
30 mM 0.1608 mL 0.8041 mL 1.6082 mL 4.0205 mL
40 mM 0.1206 mL 0.6031 mL 1.2062 mL 3.0154 mL
50 mM 0.0965 mL 0.4825 mL 0.9649 mL 2.4123 mL
60 mM 0.0804 mL 0.4021 mL 0.8041 mL 2.0103 mL
80 mM 0.0603 mL 0.3015 mL 0.6031 mL 1.5077 mL
100 mM 0.0482 mL 0.2412 mL 0.4825 mL 1.2062 mL
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ω-Hydroxy-DEET Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ω-Hydroxy-DEET72236-22-7Drug MetaboliteDHMBmajormetaboliteDEETanti-proliferativespatialrepellentirritantInhibitorinhibitorinhibit

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