2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Opioid Receptor Endogenous Metabolite
  4. [Leu5]-Enkephalin

[Leu5]-Enkephalin  (Synonyms: Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin)

Cat. No.: HY-P0288 Purity: 99.87%
COA Handling Instructions

Molarity Calculator

[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Leu5]-Enkephalin Chemical Structure

[Leu5]-Enkephalin Chemical Structure

CAS No. : 58822-25-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 37 In-stock
Solution
10 mM * 1 mL in Water USD 37 In-stock
Solid
5 mg USD 30 In-stock
10 mg USD 50 In-stock
25 mg USD 95 In-stock
50 mg USD 142 In-stock
100 mg USD 200 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of [Leu5]-Enkephalin:

[Leu5]-Enkephalin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE [Leu5]-Enkephalin

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas[1].
Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Leu5]-Enkephalin Related Antibodies
Molecular Weight

555.62

Formula

C28H37N5O7
CAS No.
Appearance

Solid

Color

White to light yellow

Sequence

Tyr-Gly-Gly-Phe-Leu
Sequence Shortening

YGGFL
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (224.97 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (179.98 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7998 mL 8.9990 mL 17.9979 mL
5 mM 0.3600 mL 1.7998 mL 3.5996 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 6.67 mg/mL (12.00 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.87%

COA (245 KB) RP-HPLC (233 KB) Elemental Analysis Report (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.7998 mL 8.9990 mL 17.9979 mL 44.9948 mL
5 mM 0.3600 mL 1.7998 mL 3.5996 mL 8.9990 mL
10 mM 0.1800 mL 0.8999 mL 1.7998 mL 4.4995 mL
15 mM 0.1200 mL 0.5999 mL 1.1999 mL 2.9997 mL
20 mM 0.0900 mL 0.4499 mL 0.8999 mL 2.2497 mL
25 mM 0.0720 mL 0.3600 mL 0.7199 mL 1.7998 mL
30 mM 0.0600 mL 0.3000 mL 0.5999 mL 1.4998 mL
40 mM 0.0450 mL 0.2250 mL 0.4499 mL 1.1249 mL
50 mM 0.0360 mL 0.1800 mL 0.3600 mL 0.8999 mL
60 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7499 mL
80 mM 0.0225 mL 0.1125 mL 0.2250 mL 0.5624 mL
100 mM 0.0180 mL 0.0900 mL 0.1800 mL 0.4499 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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[Leu5]-Enkephalin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Leu5]-Enkephalin58822-25-6Leu-enkephalin Leucine enkephalin Leucyl-enkephalinOpioid ReceptorEndogenous MetaboliteInhibitorinhibitorinhibit

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