2. Metabolic Enzyme/Protease
  3. Liposome
  4. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine

1,2-Dimyristoyl-sn-glycero-3-phosphocholine  (Synonyms: DMPC; Dimyristoyl phosphatidylcholine)

Cat. No.: HY-109541 Purity: ≥98.0%
SDS COA Handling Instructions Technical Support

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine has antiproliferative effects on various tumors. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine is used to study lipid monolayers, bilayers and drug delivery.

For research use only. We do not sell to patients.

1,2-Dimyristoyl-sn-glycero-3-phosphocholine Chemical Structure

1,2-Dimyristoyl-sn-glycero-3-phosphocholine Chemical Structure

CAS No. : 18194-24-6

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1,2-Dimyristoyl-sn-glycero-3-phosphocholine Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine has antiproliferative effects on various tumors. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine is used to study lipid monolayers, bilayers and drug delivery[1][2][3].

Cellular Effect
Cell Line Type Value Description References
MOLT-4 IC50
293 μM
Compound: DMPC
Growth inhibition of human MOLT4 cells after 5 days by MTT assay
Growth inhibition of human MOLT4 cells after 5 days by MTT assay
[PMID: 18672367]
MOLT-4 IC50
50 μM
Compound: DMPC
Growth inhibition of HIV1 3B infected human MOLT4 cells after 5 days by MTT assay
Growth inhibition of HIV1 3B infected human MOLT4 cells after 5 days by MTT assay
[PMID: 18672367]
In Vitro

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (20 mM) stabilizes Carmofur at neutral pH (pH= 5-8)[2].
1,2-Dimyristoyl-sn-glycero-3-phosphocholine (0.08-250 μM, 72 h) shows cytotoxicity on monolayer tumor cell lines SHSY-5Y, MDA-MB-435s and HT-1080, with IC50s of 214, 231 and 20 μM[2].
1,2-Dimyristoyl-sn-glycero-3-phosphocholine (12 h) distinctly enhances the ability of nanoparticles to enter PC-12 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,2-Dimyristoyl-sn-glycero-3-phosphocholine Related Antibodies
In Vivo

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC/PVP-SPIONs solution, 1 mg/mL, 10 μL, injected into the left side of the substantia nigra) could promote the diffusion of SPIONs from the substantia nigra to nearby brain regions in SD rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

677.93

Formula

C36H72NO8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (73.75 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4751 mL 7.3754 mL 14.7508 mL
5 mM 0.2950 mL 1.4751 mL 2.9502 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (7.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (7.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (244 KB) HNMR (301 KB) MS (71 KB) OR (172 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 1.4751 mL 7.3754 mL 14.7508 mL 36.8770 mL
5 mM 0.2950 mL 1.4751 mL 2.9502 mL 7.3754 mL
10 mM 0.1475 mL 0.7375 mL 1.4751 mL 3.6877 mL
15 mM 0.0983 mL 0.4917 mL 0.9834 mL 2.4585 mL
20 mM 0.0738 mL 0.3688 mL 0.7375 mL 1.8438 mL
25 mM 0.0590 mL 0.2950 mL 0.5900 mL 1.4751 mL
30 mM 0.0492 mL 0.2458 mL 0.4917 mL 1.2292 mL
40 mM 0.0369 mL 0.1844 mL 0.3688 mL 0.9219 mL
50 mM 0.0295 mL 0.1475 mL 0.2950 mL 0.7375 mL
60 mM 0.0246 mL 0.1229 mL 0.2458 mL 0.6146 mL
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1,2-Dimyristoyl-sn-glycero-3-phosphocholine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,2-Dimyristoyl-sn-glycero-3-phosphocholine18194-24-6DMPC Dimyristoyl phosphatidylcholineLiposomephospholipidliposomeslipidbilayerInhibitorinhibitorinhibit

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