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  4. 1,3,6,8-Tetrahydroxynaphthalene

1,3,6,8-Tetrahydroxynaphthalene  (Synonyms: 1,3,6,8-THN; T4HN)

Cat. No.: HY-112514 Purity: 98.82%
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1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an indispensable precursor to DHN (1,8-Dihydroxynaphthalene) melanin and is an unique symmetrical compound of polyketide origin.

For research use only. We do not sell to patients.

1,3,6,8-Tetrahydroxynaphthalene Chemical Structure

1,3,6,8-Tetrahydroxynaphthalene Chemical Structure

CAS No. : 18512-30-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 110 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 150 In-stock
25 mg USD 300 In-stock
50 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

1,3,6,8-Tetrahydroxynaphthalene Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 1,3,6,8-Tetrahydroxynaphthalene

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an indispensable precursor to DHN (1,8-Dihydroxynaphthalene) melanin and is an unique symmetrical compound of polyketide origin[1].

In Vitro

1,3,6,8-tetrahydroxynaphthalene (T4HN), an early precursor in the pentaketide pathway, is believed to be produced directly from malonyl-CoA and acetyl-CoA by type-1 polyketide synthases (PKSs)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,3,6,8-Tetrahydroxynaphthalene Related Antibodies
Molecular Weight

192.17

Formula

C10H8O4
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

OC1=C2C(O)=CC(O)=CC2=CC(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (650.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2037 mL 26.0186 mL 52.0373 mL
5 mM 1.0407 mL 5.2037 mL 10.4075 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (10.82 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2037 mL 26.0186 mL 52.0373 mL 130.0931 mL
5 mM 1.0407 mL 5.2037 mL 10.4075 mL 26.0186 mL
10 mM 0.5204 mL 2.6019 mL 5.2037 mL 13.0093 mL
15 mM 0.3469 mL 1.7346 mL 3.4692 mL 8.6729 mL
20 mM 0.2602 mL 1.3009 mL 2.6019 mL 6.5047 mL
25 mM 0.2081 mL 1.0407 mL 2.0815 mL 5.2037 mL
30 mM 0.1735 mL 0.8673 mL 1.7346 mL 4.3364 mL
40 mM 0.1301 mL 0.6505 mL 1.3009 mL 3.2523 mL
50 mM 0.1041 mL 0.5204 mL 1.0407 mL 2.6019 mL
60 mM 0.0867 mL 0.4336 mL 0.8673 mL 2.1682 mL
80 mM 0.0650 mL 0.3252 mL 0.6505 mL 1.6262 mL
100 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3009 mL
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1,3,6,8-Tetrahydroxynaphthalene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,3,6,8-Tetrahydroxynaphthalene18512-30-61,3,6,8-THN T4HNOthersInhibitorinhibitorinhibit

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