1,4-Diazabicyclo[2.2.2]octane-d₁₂ (Synonyms: Triethylenediamine-d₁₂)

Cat. No.: HY-Y0566S Purity: 99.60%: FAQs
Data Sheet SDS COA Handling Instructions

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1,4-Diazabicyclo[2.2.2]octane-d₁₂ is the deuterium labeled 1,4-Diazabicyclo[2.2.2]octane[1].

For research use only. We do not sell to patients.

1,4-Diazabicyclo[2.2.2]octane-d<sub>12</sub> Chemical Structure

1,4-Diazabicyclo[2.2.2]octane-d₁₂ Chemical Structure

CAS No. : 119451-78-4

Size	Price	Stock	Quantity
1 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of 1,4-Diazabicyclo[2.2.2]octane-d₁₂:

1,4-Diazabicyclo[2.2.2]octane Get quote

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Description

1,4-Diazabicyclo[2.2.2]octane-d₁₂ is the deuterium labeled 1,4-Diazabicyclo[2.2.2]octane[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

124.25

Formula

C₆D₁₂N₂

CAS No.

119451-78-4

Appearance

Solid

Color

White to off-white

SMILES

[2H]C1([2H])C([2H])([2H])N2C([2H])([2H])C([2H])([2H])N1C([2H])([2H])C2([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (804.83 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.0483 mL	40.2414 mL	80.4829 mL
5 mM	1.6097 mL	8.0483 mL	16.0966 mL
10 mM	0.8048 mL	4.0241 mL	8.0483 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (255 KB) HNMR (165 KB) RP-HPLC (445 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.0483 mL	40.2414 mL	80.4829 mL	201.2072 mL
	5 mM	1.6097 mL	8.0483 mL	16.0966 mL	40.2414 mL
	10 mM	0.8048 mL	4.0241 mL	8.0483 mL	20.1207 mL
	15 mM	0.5366 mL	2.6828 mL	5.3655 mL	13.4138 mL
	20 mM	0.4024 mL	2.0121 mL	4.0241 mL	10.0604 mL
	25 mM	0.3219 mL	1.6097 mL	3.2193 mL	8.0483 mL
	30 mM	0.2683 mL	1.3414 mL	2.6828 mL	6.7069 mL
	40 mM	0.2012 mL	1.0060 mL	2.0121 mL	5.0302 mL
	50 mM	0.1610 mL	0.8048 mL	1.6097 mL	4.0241 mL
	60 mM	0.1341 mL	0.6707 mL	1.3414 mL	3.3535 mL
	80 mM	0.1006 mL	0.5030 mL	1.0060 mL	2.5151 mL
	100 mM	0.0805 mL	0.4024 mL	0.8048 mL	2.0121 mL

1,4-Diazabicyclo[2.2.2]octane-d₁₂ Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,4-Diazabicyclo[2.2.2]octane-d₁₂119451-78-4Triethylenediamine-d₁₂Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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1,4-Diazabicyclo[2.2.2]octane-d12 (Synonyms: Triethylenediamine-d12)

Other Forms of 1,4-Diazabicyclo[2.2.2]octane-d12:

1,4-Diazabicyclo[2.2.2]octane-d12 Related Antibodies

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1,4-Diazabicyclo[2.2.2]octane-d12 Related Antibodies

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Complete Stock Solution Preparation Table

1,4-Diazabicyclo[2.2.2]octane-d12 Related Classifications