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  4. 1,4-Diazabicyclo[2.2.2]octane

1,4-Diazabicyclo[2.2.2]octane  (Synonyms: Triethylenediamine)

Cat. No.: HY-Y0566 Purity: 99.99%
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1,4-Diazabicyclo[2.2.2]octane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

1,4-Diazabicyclo[2.2.2]octane Chemical Structure

1,4-Diazabicyclo[2.2.2]octane Chemical Structure

CAS No. : 280-57-9

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Based on 1 publication(s) in Google Scholar

Other Forms of 1,4-Diazabicyclo[2.2.2]octane:

1,4-Diazabicyclo[2.2.2]octane Related Antibodies

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Description

1,4-Diazabicyclo[2.2.2]octane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

In Vitro

1,4-Diazabicyclo[2.2.2]octane is used as polyurethane catalyst, Balis-Hillman reaction catalyst complexing ligand and lewis base. It finds use in dye lasers and in mounting samples for fluorescence microscopy and as anti-fade reagent shown to sca Venge free radicals due to flurochrome excitation of fluorochromes. Furthermore, it is an oxidation and polymerization catalyst.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,4-Diazabicyclo[2.2.2]octane Related Antibodies
Molecular Weight

112.17

Formula

C6H12N2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N1(CC2)CCN2CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

RT, protect from light, stored under nitrogen
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (891.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.9150 mL 44.5752 mL 89.1504 mL
5 mM 1.7830 mL 8.9150 mL 17.8301 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (22.29 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (22.29 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.99%

COA (250 KB) HNMR (124 KB) GC (210 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.9150 mL 44.5752 mL 89.1504 mL 222.8760 mL
5 mM 1.7830 mL 8.9150 mL 17.8301 mL 44.5752 mL
10 mM 0.8915 mL 4.4575 mL 8.9150 mL 22.2876 mL
15 mM 0.5943 mL 2.9717 mL 5.9434 mL 14.8584 mL
20 mM 0.4458 mL 2.2288 mL 4.4575 mL 11.1438 mL
25 mM 0.3566 mL 1.7830 mL 3.5660 mL 8.9150 mL
30 mM 0.2972 mL 1.4858 mL 2.9717 mL 7.4292 mL
40 mM 0.2229 mL 1.1144 mL 2.2288 mL 5.5719 mL
50 mM 0.1783 mL 0.8915 mL 1.7830 mL 4.4575 mL
60 mM 0.1486 mL 0.7429 mL 1.4858 mL 3.7146 mL
80 mM 0.1114 mL 0.5572 mL 1.1144 mL 2.7859 mL
100 mM 0.0892 mL 0.4458 mL 0.8915 mL 2.2288 mL
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1,4-Diazabicyclo[2.2.2]octane Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,4-Diazabicyclo[2.2.2]octane280-57-9TriethylenediamineBiochemical Assay Reagentsbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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