2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. 1-Naphthaleneacetic acid

1-Naphthaleneacetic acid  (Synonyms: 1-Naphthylacetic acid)

Cat. No.: HY-18570 Purity: 99.89%
SDS COA Handling Instructions

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1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM.

For research use only. We do not sell to patients.

1-Naphthaleneacetic acid Chemical Structure

1-Naphthaleneacetic acid Chemical Structure

CAS No. : 86-87-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 22 In-stock
Solution
10 mM * 1 mL in DMSO USD 22 In-stock
Solid
500 mg USD 20 In-stock
5 g USD 30 In-stock
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50 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of 1-Naphthaleneacetic acid:

1-Naphthaleneacetic acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM[1][2].

IC50 & Target[1]

PLA2

13.16 μM (IC50)

In Vitro

1-Naphthaleneacetic acid (0.7-14 μM) inhibits the activity of PLA2, with the Ki and IC50 of 6.87 μM and 13.16 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Naphthaleneacetic acid Related Antibodies
Molecular Weight

186.21

Formula

C12H10O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CC1=CC=CC2=C1C=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Methanol : 125 mg/mL (671.29 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (537.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3703 mL 26.8514 mL 53.7028 mL
5 mM 1.0741 mL 5.3703 mL 10.7406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (13.43 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (13.43 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.89%

SDS (555 KB)

COA (251 KB) LCMS (129 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 5.3703 mL 26.8514 mL 53.7028 mL 134.2570 mL
5 mM 1.0741 mL 5.3703 mL 10.7406 mL 26.8514 mL
10 mM 0.5370 mL 2.6851 mL 5.3703 mL 13.4257 mL
15 mM 0.3580 mL 1.7901 mL 3.5802 mL 8.9505 mL
20 mM 0.2685 mL 1.3426 mL 2.6851 mL 6.7129 mL
25 mM 0.2148 mL 1.0741 mL 2.1481 mL 5.3703 mL
30 mM 0.1790 mL 0.8950 mL 1.7901 mL 4.4752 mL
40 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3564 mL
50 mM 0.1074 mL 0.5370 mL 1.0741 mL 2.6851 mL
60 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2376 mL
80 mM 0.0671 mL 0.3356 mL 0.6713 mL 1.6782 mL
100 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3426 mL
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1-Naphthaleneacetic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Naphthaleneacetic acid86-87-31-Naphthylacetic acidPhospholipaseauxinplantgrowthPLA2Inhibitorinhibitorinhibit

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